Analyse the fundamental mechanisms  of extracellular matrix organisation in tissues.

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Describe and evaluate tissue response to insults.

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Propose and test innovative therapeutic approaches.

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A new molecular signature to better identify radiosensitive patients

A study co-piloted by researchers from the LGRK (IRCM / CEA-Jacob) and the LBTI (Université Claude Bernard Lyon 1) and carried out on cells from patients who developed severe side effects following radiotherapy, enabled the identification of a new molecular signature of the radiosensitivity of healthy tissues. These results, published in Frontiers in Oncology, show

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A new mechanism regulating wound healing revealed by the LBTI

3 groups of the LBTI worked together to understand how the BMP-1 metalloprotease can regulate cell adhesion and corneal wound healing through the cleavage of the matricellular protein thrombospondin-1. This work is just published in Science Signaling and has been selected to be featured on the journal cover.

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LBTI starts the formulation of promising antiviral drugs against Covid-19 for pulmonary delivery

CovidNanoMed project: “Nanoformulations of current therapeutic drug candidates against SARS-CoV-2 for pulmonary delivery”. ANR Flash Covid-19 – PI: Bernard Verrier The team of B. Verrier, with the help of the group of R. Terreux for bioinformatics and  a partnership with CEA and INRAE, have now started the identification of several promising antiviral candidates among

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Nouvelles technologies de single-molecule FISH multiplex (RNAscope – ACD)

Jeudi 20 février: présentation des technologies de FISH-RNAscope par la société BioTechne, 3ème étage (pallier)

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