LBTI (Tissue Biology and Therapeutic Engineering Laboratory) is a leading French research laboratory specializing in the study of healthy and diseased tissues and in the development of innovative therapeutic strategies with high potential for translation toward clinical applications.
We have strong expertise in tissues such as skin, cartilage, teeth, cornea and mucosae. Our specific research aims are:
> to analyse the basic mechanisms of tissue organization and homeostasis, and to identify potential therapeutic targets
> to understand and model the tissue response to physiological or pathological stress (including mechanical stress and aging)
> to develop novel therapeutic approaches for tissue repair and targeted delivery of therapeutic agents
Our laboratory provides a highly multidisciplinary environment, gathering chemists, biochemists, cell and molecular biologists, bio-informaticians, physiologists, physicians and galenic experts.
LBTI is a joint research unit of the CNRS and the Université Claude Bernard Lyon 1 (UMR 5305), hosted by the Institute for the Biology and Chemistry of Proteins (IBCP), in the bio-campus of Lyon – Gerland. Directed by Dominique Sigaudo-Roussel, it is organized into 6 research groups. As a contributor of the Unité Mixte de Recherche UMS 3444 (SFR Biosciences), LBTI has access to cutting-edge technological facilities and benefits from a highly dynamic and interactive scientific environment for both fundamental and translational research.
The research developed by the 5 groups present at LBTI are gathered under 3 main topics :
– matrix organisation in tissues and synthetic materials
– wound healing and skin functionality
– therapeutic molecules and advanced therapy medicinal products
|Research groups at LBTI||Group leader
|Skin functional integrity||B. Fromy and J. Lamartine
|Cell/Microenvironement cross-talk and tissue repair||P. Rousselle|
|Matricellular proteins and pathological deregulations||U. Valcourt
|Metalloproteinases and tissue remodeling||C. Moali|
|Osteoarticular and dental research||F. Mallein-Gerin|
|Colloid vectors and tissue transport||B. Verrier|