Introduction
Bone, cartilage and tooth are tissues that make up the skeleton. They are essential to vital functions such as the growth of the organism, organ protection, movement and mastication. Our team studies the sane and pathological physiology of these tissues, focusing on cartilage and the dental pulp. Our approach consists in combining fundamental and translational research, around three main themes:
- Interactions between cells and the extracellular matrix
- Tissue repair and regeneration mechanisms
- Biomimetic tissue engineering
Together with hospital practitioners, we are developing a multidisciplinary research with a clinical scope, which involves 3D printing, cell therapy and tissue engineering for the reconstruction of articular cartilage and nasal cartilage, as well as the dental pulp.
Themes
Our group takes advantage of its long-term studies on chondrocyte differentiation and cartilage development to set up new protocols to repair cartilage, in collaboration with hospitals and industries. More specifically, we analyze :
- Biomaterial functionalization for cartilage tissue engineering (JD. Malcor)
- Mechanotransduction of chondrocytes (M. Pasdeloup & J. Lafont)
- Epigenetics during osteoarthritis (J. Lafont)
- Nasal chondrocytes for cartilage tissue engineering (M. Pasdeloup & JD. Malcor)
- Innovative antibacterial hydrogels for dental pulp regeneration (M. Ducret)
Keywords : tissue engineering, cartilage and dental pulp repair, extracellular matrix, collagen, mechano-transduction, functionalized biomaterials, osteoarthritis, dental pulp inflammation
Members : ROAD group
Publications : Publications ROAD group
Contact
ROAD group (osteoarticular and dental research)
Laboratoire de Biologie Tissulaire et Ingénierie thérapeutique – CNRS UMR 5305 – University Claude Bernard Lyon 1
Institut de Biologie et Chimie des Protéines
7, passage du Vercors 69367 LYON CEDEX 07
FRANCE
E-mail : f.mallein-gerin@ibcp.fr
Tel : +33 (0)4-37-65-29-19
Fax : +33 (0)4-72-72-26-04
