Author Archives: Catherine Moali

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A study from the SKIN group suggest that cells in aged tissues transmit aging messages to neighbouring cells

Communication defects between the cells that make tissues represent a  possible cause of aging. In a study published on November 30, 2024 in the journal Aging, researchers from the SKIN team show that cells from aged skin produce a larger quantity of vesicles, whose molecular content is different from that of vesicles from cells from young skin. These results suggest that some cells in aged tissues may be transmitting a message of aging with a possible remote impact on the behavior of neighboring cells. Link to the publication

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Identification of the endogenous and specific inhibitor of BMP-1/tolloid-like proteinases by the Moali group

BMP-1/tolloid-like proteinases (or BTPs) are critical players during development and tissue repair. While most proteases are regulated by endogenous and specific inhibitors which protect tissues from excessive proteolytic activity, the existence of such an inhibitor in the case of mammalian BTPs has remained elusive. In a study published on December 4th, 2023 in Nature Communications, the Moali group evidenced that the protein known as PCPE-2 is the long-awaited inhibitor of BTPs. This result was very much unexpected as PCPE-2 was previously described as an enhancer of BTP activity.  More detail can be found here

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Congratulations to Manon Napoli for the SFBMEc best oral communication award

Manon Napoli (Metalloproteases and Tissue Remodeling team) was awarded the prize for best oral presentation at the annual meeting of the French Society for Extracellular Matrix Biology (SFBMEc), held in Strasbourg on November 16-17, 2023. One week earlier, Manon had already been awarded the prize for best oral communication at the 28th scientific day of the EDISS doctoral school. Brilliant!

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Patricia Rousselle was awarded the CNRS Innovation Medal : congratulations !

Patricia Rousselle, who is a group leader at LBTI, was recently awarded the CNRS Innovation Medal. Her work is focused on skin wound healing and regeneration and led to the development of several bio-inspired molecules with great pharmaceutical and cosmetic potential. Read more

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Congratulations to Claire Monge who was awarded the CNRS Bronze Medal !

What if it was possible to take a vaccine that would dissolve under the tongue instead of getting an injection ? It is the challenge of Claire Monge’s work. Her research in therapeutic engineering aims at developing bio-inspired and eco-friendly vaccines to be administered through mucosae. Her original and promising immunization approach is based on a patch delivering an active substance after its dissolution in the buccal cavity. By targeting mucosae, her research work has great potential for a large diversity of infections, from the respiratory to the genital tracts. To bolster the clinical transfer of her studies, Claire Monge uses an integrated approach, from formulation to preclinical trials. More on Claire Monge’s work here

Claire Monge obtained her PhD in Physiology-Pharmacology from the Université of Grenobles-Alpes (UGA) in 2009, then she moved to the Nijmegen Centre for Molecular Life Sciences (NCMLS, Nijmegen, NL). Back to France, she made a 4-year post-doc in Catherine Picart’s group at LGMP (Laboratoire des Matériaux et du Génie Physique, Grenoble). Since 2017, she is a CNRS “chargé de recherche” at LBTI where she is the co-leader of a research group with B. Verrier. She is also in charge of the LBTI communication group, LBTI officer for Professional Equality and on the board of the French Society of Nanomedecine (SFNano). Congratulations again for this medal which recognizes young talented CNRS researchers !