Identification of the endogenous and specific inhibitor of BMP-1/tolloid-like proteinases by the Moali group
BMP-1/tolloid-like proteinases (or BTPs) are critical players during development and tissue repair. While most proteases are regulated by endogenous and specific inhibitors which protect tissues from excessive proteolytic activity, the existence of such an inhibitor in the case of mammalian BTPs has remained elusive. In a study published on December 4th, 2023 in Nature Communications, the Moali group evidenced that the protein known as PCPE-2 is the long-awaited inhibitor of BTPs. This result was very much unexpected as PCPE-2 was previously described as an enhancer of BTP activity. More detail can be found here
