Author Archives: Catherine Moali

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Le LBTI recrute des (enseignants)-chercheurs

We are looking for junior or senior researchers with international experience to develop and extend LBTI main research topics. Some examples of topics which are of high interest for us are the following :
– tissue response to injury / repair / inflammation / neoplasia
– aging
– extracellular matrix organization / remodeling / signaling /epigenetics
– tissue engineering / biomaterials
– nanovectors / drug delivery / molecular targets / drug and protein design
– stem cells / cell therapy
– biomechanics / mechanotransduction

Depending on their level of experience, applicants can be integrated in one of the LBTI groups or apply for funding to work as independant researchers (ATIPE Avenir, ANR, ERC etc).
Successful candidates will also have the support of the LBTI members to prepare their applications to research organisms (CNRS, University).

Candidates can send their application file (CV, list of publications, cover letter and references) to Bernard Verrier (bernard.verrier@ibcp.fr) or to one of the LBTI group leaders.


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Innovations for cosmetics – Les travaux de l’équipe Rousselle à l’honneur dans CNRS News

On the occasion of Cosmetic-360, an international trade fair for innovation in the cosmetics industry being held in Paris this week, a quick overview of ongoing research in CNRS laboratories, which are already at work on the cosmetics of the future.

Lire l’article complet : https://news.cnrs.fr/articles/innovations-for-cosmetics


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PhD position – Identification of extracellular matrix-derived therapeutic targets and biomarkers in dystrophic epidermolysis bullosa skin wounds

Dystrophic epidermolysis bullosa (DEB) is a rare skin blistering disorder caused by mutations in COL7A1 encoding the anchoring fibril protein collagen VII. The most severe forms are characterized by soft tissue fibrosis, which significantly contributes to disease morbidity and drives the major cause of death in severe DEB, that is cutaneous squamous cell carcinoma (cSCC). Some efforts to develop causal therapies have been successful but larger implementation is hampered by concerns surrounding efficacy, delivery, safety and costs. An alternative, which has shown preclinical success is to target changes occurring subsequent to skin fragility. The innovative nature of this proposal is to comprehensively analyze the main breeding ground of disease complications linked to fibrotic dermal ECM, to better understand how it is established and to derive much-needed biomarkers of disease progression. These studies will also pave the way towards the identification of novel relevant therapeutic targets, which could help to control aberrant skin remodeling and turn a severe disease into a milder disease.

The PhD student will be in charge of the analyses of DEB skin cultures and biopsies using electron microscopy, immuno-detection and proteomics. Both shotgun and targeted (MRM) proteomic approaches will be used and one major objective will be to adapt specific protocols allowing the enrichment of extracellular matrix proteins in tissue samples. He/she will be co-supervised by C. Moali and P. Rousselle (Group leaders, LBTI).

The PhD position is funded by ANR and the work will be performed in collaboration with the Department of Dermatology, Medical Center – University of Freiburg, Germany (A. Nyström and D. Kiritsi). Exchange programs between the two labs will be established.

  • Applications :

Applicants should submit their complete application file (CV; cover letter; one-page summary of the Master dissertation; grades for the Master or the engineering degree; at least two references) before January 8, 2019 via the cnrs job portal : https://emploi.cnrs.fr (offer reference : “PhD student (M/F) in extracellular matrix biology and skin physiology” UMR5305-CATMOA-002)


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Les travaux de l’équipe Moali dans le document “2017, une année avec le CNRS en Rhône Auvergne”

Les travaux de l’équipe Métalloprotéases et Remodelage Tissulaire publiés en 2017 dans Nature Communications sur l’assemblage des trimères de collagène I font partie des faits marquants sélectionnés par la délégation CNRS Rhône-Auvergne pour illustrer les avancées scientifiques de 2017.

Télécharger l’article original de Nature Communications : ncomms14671

Télécharger le document “2017, une année avec le CNRS en Rhône Auvergne”: ra_cnrs2017_rhoneauvergne_vdefweb


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David Hulmes honored by ISMB at MBE2018

David Hulmes has received the ISMB (International Society for Matrix Biology) award at Matrix Biology Europe 2018 for its outstanding contribution to the Society throughout the years. David was ISMB president between 2010 and 2012 and is the present treasurer of the society until the end of 2018.