QUESTION 4: HOW THE FUNCTIONALITY OF THE COMPROMISED SKIN CAN BE RECOVERED?

Chronic wound is due to a defect in the healing process and puts at risk the entire body to infection and further health complications. Up-to-now, wound healing studies in the skin mainly focused on the re-epithelialization phase. However, beside this crucial step, almost no investigations have reported the quality of the repaired dermis which is crucial to prevent any relapses. In this research axis, we investigate the signaling mechanisms involved in the healing process of pressure-induced wounds and we attempt to develop therapeutic strategies to improve the quality of the repaired skin. These therapeutic strategies are mainly based on the administration of small soluble molecules (anti-oxidant, anti-glycation and angiogenic treatments), exosomes, functionalized nanoparticles with RNAs (in collaboration with Verrier’s team), smart dressings. Our main challenge here is to improve the delivery of effective factors at a specific time/phase of the wound healing that could be performed in cascade with multiple time release. In addition, because NaCl balance perturbations affect skin vascular reactivity and in turns its fragility, we are exploring the benefit of a low NaCl diet in a mouse model with metabolic syndrome.

Participants: C Bonod, L Dubourg, B Fromy, A Josset-Lamaugarny, J Lamartine, M Lo, KL Liu, N Picard, D Sigaudo-Roussel, J Vial

Collaborations: F Berthod (LOEX Canada), M Roustit (HP2 Grenoble)

Fundings: ANR PGI2Heal, Urgo STEVIA.