Nicolas PICARD
Chargé de recherche CNRS
https://orcid.org/0000-0002-1695-3389
Doctorat de l’Université de Paris 6 (Pierre et Marie Curie) 2006
Précédents laboratoires :
CNRS ERL 8228 Métabolisme et physiologie rénale, Paris (Directeur : Aurélie Edwards) 2013-2018
PARCC - Paris Centre de recherche Cardiovasculaire (PARCC) – INSERM UMR 970
Equipe 12 : « Pathophysiologie du tubule rénal, homéostasie et pression artérielle »
(Directeur : Dominique Eladari) 2012-2013
CNRS ERL 7226 ; Centre de recherche des Cordeliers (Directeur : Alain Doucet), Paris 2010-2012
Institute of Anatomy, Zurich, Switzerland 2007-2010
Encadrant : Pr Johannes Loffing
Institute of Anatomy, Zurich, Switzerland 2006-2007
Encadrant : Pr Brigitte Kaissling
Nicolas Picard (Lab for tissue biology and therapeutic engineering, Lyon, UMR5305 CNRS) is a specialist in kidney morphology and in regulatory mechanisms of renal ion transport. He recently joined the group in Lyon where he develops projects on organ architecture maintenance and its functional integrity (kidney, skin) in adults. He published about 35 articles mainly on ion transport regulation in the distal nephron. His recent research work focus on the participation of renal intercalated cells to NaCl and H+ handling. He also investigates signaling pathways by using high throughtput techniques on isolated nephron segment and renal cells.
Mots clés : Homéostasie du sodium et troubles électrolytique, Physiologie rénale Microcirculation cutanée
Equipe : Intégrité Fonctionnelle du Tissu Cutané
Courriel : nicolas.picard@ibcp.fr
Téléphone : +33(0)4-72-72-26-92
Statut : Chargé de recherches
55 publications au total. Seules les 5 dernières années sont affichées
2023
55. ClC-K Kidney Chloride Channels: From Structure to Pathology.
Andrini O, Eladari D, Picard N
(2023) Handb Exp Pharmacol :
2019
54. TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells.
Arhatte M, Gunaratne Gs, El Boustany C, Kuo Iy, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-gervais S, Ehrlich Be, Marchant Js, Savage Am, Van Eeden Fjm, Wilkinson Rn, Demolombe S, Honore E, Patel A
(2019) Nat Commun 10 :2024-2024
2017
53. Editorial.
Becquemont L, Picard N, Verstuyft C
(2017) Therapie 72 :173-174
52.
Becquemont L, Picard N, Verstuyft C
(2017) Therapie 72 :171-172
51. Cutaneous and renal vasodilatory response to local pressure application: A comparative study in mice.
Begey Al, Liu Kl, Lo M, Josset-lamaugarny A, Picard N, Gauthier C, Fromy B, Sigaudo-roussel D, Dubourg L
(2017) Microvasc Res 115 :44-51
50. Towards therapeutic drug monitoring of everolimus in cancer? Results of an exploratory study of exposure-effect relationship.
Deppenweiler M, Falkowski S, Saint-marcoux F, Monchaud C, Picard N, Laroche Ml, Tubiana-mathieu N, Venat-bouvet L, Marquet P, Woillard Jb
(2017) Pharmacol Res 121 :138-144
49. Characterization and identification of eight designer benzodiazepine metabolites by incubation with human liver microsomes and analysis by a triple quadrupole mass spectrometer.
El Balkhi S, Chaslot M, Picard N, Dulaurent S, Delage M, Mathieu O, Saint-marcoux F
(2017) Int J Legal Med 131 :979-988
48. The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.
Hennings Jc, Andrini O, Picard N, Paulais M, Huebner Ak, Cayuqueo Ik, Bignon Y, Keck M, Corniere N, Bohm D, Jentsch Tj, Chambrey R, Teulon J, Hubner Ca, Eladari D
(2017) J Am Soc Nephrol 28 :209-217
47. Intercalated Cell Depletion and Vacuolar H(+)-ATPase Mistargeting in an Ae1 R607H Knockin Model.
Mumtaz R, Trepiccione F, Hennings Jc, Huebner Ak, Serbin B, Picard N, Ullah Akms, P?unescu Tg, Capen De, Lashhab Rm, Mouro-chanteloup I, Alper Sl, Wagner Ca, Cordat E, Brown D, Eladari D, Hubner Ca
(2017) J Am Soc Nephrol 28 :1507-1520
46. Pharmacogenetics-based personalized therapy: Levels of evidence and recommendations from the French Network of Pharmacogenetics (RNPGx).
Picard N, Boyer Jc, Etienne-grimaldi Mc, Barin-le Guellec C, Thomas F, Loriot Ma,
(2017) Therapie 72 :185-192
45.
Picard N, Boyer Jc, Etienne-grimaldi Mc, Barin-le Guellec C, Thomas F, Loriot Ma,
(2017) Therapie 72 :175-183
44. Pharmacogenetics of immunosuppressants: State of the art and clinical implementation - recommendations from the French National Network of Pharmacogenetics (RNPGx).
Woillard Jb, Chouchana L, Picard N, Loriot Ma,
(2017) Therapie 72 :285-299
43.
Woillard Jb, Chouchana L, Picard N, Loriot Ma,
(2017) Therapie 72 :269-284
2016
42. Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity?
Billat Pa, Woillard Jb, Essig M, Sauvage Fl, Picard N, Alain S, Neely M, Marquet P, Saint-marcoux F
(2016) J Antimicrob Chemother 71 :484-9
41. Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation.
Brunet M, Shipkova M, Van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, Lopez-hoyos M, Barten Mj, Bergan S, Picard N, Millan Lopez O, Marquet P, Hesselink Da, Noceti O, Pawinski T, Wallemacq P, Oellerich M
(2016) Ther Drug Monit 38 Suppl 1 :S1-20
40. Influence of Donor and Recipient CYP3A4, CYP3A5, and ABCB1 Genotypes on Clinical Outcomes and Nephrotoxicity in Liver Transplant Recipients.
Debette-gratien M, Woillard Jb, Picard N, Sebagh M, Loustaud-ratti V, Sautereau D, Samuel D, Marquet P
(2016) Transplantation 100 :2129-2137
39. Positive biodiversity-productivity relationship predominant in global forests.
Liang J, Crowther Tw, Picard N, Wiser S, Zhou M, Alberti G, Schulze Ed, Mcguire Ad, Bozzato F, Pretzsch H, De-miguel S, Paquette A, Herault B, Scherer-lorenzen M, Barrett Cb, Glick Hb, Hengeveld Gm, Nabuurs Gj, Pfautsch S, Viana H, Vibrans Ac, Ammer C, Schall P, Verbyla D, Tchebakova N, Fischer M, Watson Jv, Chen Hy, Lei X, Schelhaas Mj, Lu H, Gianelle D, Parfenova Ei, Salas C, Lee E, Lee B, Kim Hs, Bruelheide H, Coomes Da, Piotto D, Sunderland T, Schmid B, Gourlet-fleury S, Sonke B, Tavani R, Zhu J, Brandl S, Vayreda J, Kitahara F, Searle Eb, Neldner Vj, Ngugi Mr, Baraloto C, Frizzera L, Ba?azy R, Oleksyn J, Zawi?a-nied?wiecki T, Bouriaud O, Bussotti F, Finer L, Jaroszewicz B, Jucker T, Valladares F, Jagodzinski Am, Peri Pl, Gonmadje C, Marthy W, O'brien T, Martin Eh, Marshall Ar, Rovero F, Bitariho R, Niklaus Pa, Alvarez-loayza P, Chamuya N, Valencia R, Mortier F, Wortel V, Engone-obiang Nl, Ferreira Lv, Odeke De, Vasquez Rm, Lewis Sl, Reich Pb
(2016) Science 354 :
38. Efficiency and Safety of an Early Dose Adjustment of Ribavirin in Patients Infected With Hepatitis C Underexposed to the Drug and Treated With Peginterferon Ribavirin.
Loustaud-ratti V, Maynard M, Thevenon S, Pradat P, Rousseau A, Alain S, Deny P, Gagnieu Mc, Tran A, Dao T, Silvain C, Lunel-fabiani F, Picard N, Zublena I, Marquet P, Trepo C,
(2016) Ther Drug Monit 38 :684-692
37. Piezo1-dependent regulation of urinary osmolarity.
Martins Jr, Penton D, Peyronnet R, Arhatte M, Moro C, Picard N, Kurt B, Patel A, Honore E, Demolombe S
(2016) Pflugers Arch 468 :1197-206
36. Inactivation of the Dorsal Premotor Area Disrupts Internally Generated, But Not Visually Guided, Sequential Movements.
Ohbayashi M, Picard N, Strick Pl
(2016) J Neurosci 36 :1971-6
35. Chronic Administration of the N-Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype.
Patrizi A, Picard N, Simon Aj, Gunner G, Centofante E, Andrews Na, Fagiolini M
(2016) Biol Psychiatry 79 :755-64
34. Pharmacogenetic Biomarkers Predictive of the Pharmacokinetics and Pharmacodynamics of Immunosuppressive Drugs.
Picard N, Bergan S, Marquet P, Van Gelder T, Wallemacq P, Hesselink Da, Haufroid V
(2016) Ther Drug Monit 38 Suppl 1 :S57-69
33. A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation.
Pouche L, Koitka M, Stojanova J, Woillard Jb, Monchaud C, Villeneuve C, Essig M, Abraham J, Le Meur Y, Rerolle Jp, Kamar N, Rostaing L, Merville P, Gandia P, Bouchet S, Petersen Bs, Marquet P, Picard N
(2016) Pharmacogenomics 17 :375-91
32. New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs.
Pouche L, Stojanova J, Marquet P, Picard N
(2016) Pharmacogenomics 17 :277-96
31. Therapeutic Drug Monitoring of Everolimus: A Consensus Report.
Shipkova M, Hesselink Da, Holt Dw, Billaud Em, Van Gelder T, Kunicki Pk, Brunet M, Budde K, Barten Mj, De Simone P, Wieland E, Lopez Om, Masuda S, Seger C, Picard N, Oellerich M, Langman Lj, Wallemacq P, Morris Rg, Thompson C, Marquet P
(2016) Ther Drug Monit 38 :143-69
30. Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation.
Shipkova M, Lopez Om, Picard N, Noceti O, Sommerer C, Christians U, Wieland E
(2016) Ther Drug Monit 38 Suppl 1 :S80-92
29. Genetic polymorphisms in the immune response: A focus on kidney transplantation.
Stojanova J, Pouche L, Picard N
(2016) Clin Biochem 49 :363-76
28. Cortical Feedback Regulates Feedforward Retinogeniculate Refinement.
Thompson Ad, Picard N, Min L, Fagiolini M, Chen C
(2016) Neuron 91 :1021-1033
27. Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
Trepiccione F, Gerber Sd, Grahammer F, Lopez-cayuqueo Ki, Baudrie V, P?unescu Tg, Capen De, Picard N, Alexander Rt, Huber Tb, Chambrey R, Brown D, Houillier P, Eladari D, Simons M
(2016) J Am Soc Nephrol 27 :3320-3330
26. Does Epoetin Beta Still Have a Place in Peginterferon Alpha-2a Plus Ribavirin Treatment Strategies for Chronic Hepatitis C?
Veillon P, Fouchard-hubert I, Larrey D, Dao Mt, D'alteroche L, Boyer-darrigand N, Picard N, Le Guillou-guillemette H, Saulnier P, Ducancelle A, Loustaud-ratti V, Lunel-fabiani F
(2016) J Interferon Cytokine Res 36 :204-14
2015
25. SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution.
Schwartz Gj, Gao X, Tsuruoka S, Purkerson Jm, Peng H, D'agati V, Picard N, Eladari D, Al-awqati Q
(2015) J Clin Invest 125 :4365-74
24. Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency.
Todkar A, Picard N, Loffing-cueni D, Sorensen Mv, Mihailova M, Nesterov V, Makhanova N, Korbmacher C, Wagner Ca, Loffing J
(2015) J Am Soc Nephrol 26 :425-38
2014
23. Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation.
Eladari D, Chambrey R, Picard N, Hadchouel J
(2014) Cell Mol Life Sci 71 :2879-95
22. Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension.
Picard N, Trompf K, Yang Cl, Miller Rl, Carrel M, Loffing-cueni D, Fenton Ra, Ellison Dh, Loffing J
(2014) J Am Soc Nephrol 25 :511-22
2013
21. The absence of intrarenal ACE protects against hypertension.
Gonzalez-villalobos Ra, Janjoulia T, Fletcher Nk, Giani Jf, Nguyen Mt, Riquier-brison Ad, Seth Dm, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-peterdi J, Navar Lg, Bernstein Ke, Mcdonough Aa
(2013) J Clin Invest 123 :2011-23
20. Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension.
Jacques T, Picard N, Miller Rl, Riemondy Ka, Houillier P, Sohet F, Ramakrishnan Sk, Busst Cj, Jayat M, Corniere N, Hassan H, Aronson Ps, Hennings Jc, Hubner Ca, Nelson Rd, Chambrey R, Eladari D
(2013) J Am Soc Nephrol 24 :1104-13
19. SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.
Li X, Sanneman Jd, Harbidge Dg, Zhou F, Ito T, Nelson R, Picard N, Chambrey R, Eladari D, Miesner T, Griffith Aj, Marcus Dc, Wangemann P
(2013) Plos Genet 9 :e1003641-e1003641
2012
18. A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.
Hennings Jc, Picard N, Huebner Ak, Stauber T, Maier H, Brown D, Jentsch Tj, Vargas-poussou R, Eladari D, Hubner Ca
(2012) Embo Mol Med 4 :1057-71
2011
17. Role of tissue kallikrein in regulation of tubule function.
Chambrey R, Picard N
(2011) Curr Opin Nephrol Hypertens 20 :523-8
16. Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.
Paulais M, Bloch-faure M, Picard N, Jacques T, Ramakrishnan Sk, Keck M, Sohet F, Eladari D, Houillier P, Lourdel S, Teulon J, Tucker Sj
(2011) Proc Natl Acad Sci U S A 108 :10361-6
2010
15. Tissue kallikrein permits early renal adaptation to potassium load.
El Moghrabi S, Houillier P, Picard N, Sohet F, Wootla B, Bloch-faure M, Leviel F, Cheval L, Frische S, Meneton P, Eladari D, Chambrey R
(2010) Proc Natl Acad Sci U S A 107 :13526-31
14. Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells.
Koesters R, Kaissling B, Lehir M, Picard N, Theilig F, Gebhardt R, Glick Ab, Hahnel B, Hosser H, Grone Hj, Kriz W
(2010) Am J Pathol 177 :632-43
13. Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.
Picard N, Capuano P, Stange G, Mihailova M, Kaissling B, Murer H, Biber J, Wagner Ca
(2010) Pflugers Arch 460 :677-87
2009
12. Tissue kallikrein deficiency and renovascular hypertension in the mouse.
Griol-charhbili V, Sabbah L, Colucci J, Vincent Mp, Baudrie V, Laude D, Elghozi Jl, Bruneval P, Picard N, Meneton P, Alhenc-gelas F, Richer C
(2009) Am J Physiol Regul Integr Comp Physiol 296 :R1385-91
2008
11. Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption.
Nowik M, Picard N, Stange G, Capuano P, Tenenhouse Hs, Biber J, Murer H, Wagner Ca
(2008) Pflugers Arch 457 :539-49
10. Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat.
Picard N, Baum O, Vogetseder A, Kaissling B, Le Hir M
(2008) Histochem Cell Biol 130 :141-55
9. Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney.
Pizard A, Richer C, Bouby N, Picard N, Meneton P, Azizi M, Alhenc-gelas F
(2008) Biol Chem 389 :701-6
8. Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells.
Vogetseder A, Picard N, Gaspert A, Walch M, Kaissling B, Le Hir M
(2008) Am J Physiol Cell Physiol 294 :C22-8
2007
7. Immunolocalization of phospho-S6 kinases: a new way to detect mitosis in tissue sections and in cell culture.
Schmidt T, Wahl P, Wuthrich Rp, Vogetseder A, Picard N, Kaissling B, Le Hir M
(2007) Histochem Cell Biol 127 :123-9
2006
6. Mice chronically fed a westernized experimental diet as a model of obesity, metabolic syndrome and osteoporosis.
Demigne C, Bloch-faure M, Picard N, Sabboh H, Besson C, Remesy C, Geoffroy V, Gaston At, Nicoletti A, Hagege A, Menard J, Meneton P
(2006) Eur J Nutr 45 :298-306
5. Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.
Gkika D, Topala Cn, Chang Q, Picard N, Thebault S, Houillier P, Hoenderop Jg, Bindels Rj
(2006) Embo J 25 :4707-16
4. Pendrin regulation in mouse kidney primarily is chloride-dependent.
Vallet M, Picard N, Loffing-cueni D, Fysekidis M, Bloch-faure M, Deschenes G, Breton S, Meneton P, Loffing J, Aronson Ps, Chambrey R, Eladari D
(2006) J Am Soc Nephrol 17 :2153-63
2005
3. Genetic ablation of Rhbg in the mouse does not impair renal ammonium excretion.
Chambrey R, Goossens D, Bourgeois S, Picard N, Bloch-faure M, Leviel F, Geoffroy V, Cambillau M, Colin Y, Paillard M, Houillier P, Cartron Jp, Eladari D
(2005) Am J Physiol Renal Physiol 289 :F1281-90
2. Tissue kallikrein-deficient mice display a defect in renal tubular calcium absorption.
Picard N, Van Abel M, Campone C, Seiler M, Bloch-faure M, Hoenderop Jg, Loffing J, Meneton P, Bindels Rj, Paillard M, Alhenc-gelas F, Houillier P
(2005) J Am Soc Nephrol 16 :3602-10
2004
1. Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels.
Gogelein H, Brendel J, Steinmeyer K, Strubing C, Picard N, Rampe D, Kopp K, Busch Ae, Bleich M
(2004) Naunyn Schmiedebergs Arch Pharmacol 370 :183-92
