Mini Curriculum Vitae

Catherine MOALI

PhotoMOALI
Ingénieure Chimiste ESPCI-ParisTech (1995)
Diplômée de l’Institut de Formation Supérieure Biomédicale (IFSBM, Université Paris Sud, 1998)
Doctorat de l’Université Paris Sud (1999)
HDR de l’Université Claude Bernard Lyon I (2011)

Précédents laboratoires :

– Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Paris (1994-1999)
– Centre d’Ingénierie des Protéines, Liège (1999-2001)
– Institut de Biologie et Chimie des Protéines, Lyon (2001-2010)

Responsable de l’Equipe Métalloprotéases et Remodelage Tissulaire
Directrice adjointe de la SFR Biosciences (http://www.sfr-biosciences.fr/)

Mots-clés : Métalloprotéases, Matrice Extracellulaire, TGF-?, Cicatrisation, Fibroses, Protéomique, Interactions Protéines-Protéines


Equipe : Métalloprotéases et Remodelage tissulaire
Courriel : catherine.moali@ibcp.fr
Téléphone : +33(0)4-72-72-26-38
Statut : Directeur de recherches


2019
36.  COL1A1 C-propeptide mutations cause ER mislocalization of procollagen and impair C-terminal procollagen processing. 
Barnes Am, Ashok A, Makareeva En, Brusel M, Cabral Wa, Weis M, Moali C, Bettler E, Eyre Dr, Cassella Jp, Leikin S, Hulmes Djs, Kessler E, Marini Jc
(2019) Biochim Biophys Acta Mol Basis Dis  :  Icon PUBMED

35.  A scaffold- and serum-free method to mimic human stable cartilage validated by secretome. 
Cortes I, Matsui Ram, Azevedo Ms, Beatrici A, Souza Kla, Launay G, Delolme F, Granjeiro Jm, Moali C, Baptista Ls
(2019) Tissue Eng Part A  :  Icon PUBMED

34.  C-terminal proteolysis of the collagen VI ?3 chain by BMP-1 and proprotein convertase(s) releases endotrophin in fragments of different sizes. 
Heumuller Se, Talantikite M, Napoli M, Armengaud J, Morgelin M, Hartmann U, Sengle G, Paulsson M, Moali C, Wagener R
(2019) J Biol Chem 294 :13769-13780  Icon PUBMED

33.  Degradome of soluble ADAM10 and ADAM17 metalloproteases. 
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-arras D, Rose-john S, Moali C, Lichtenthaler Sf, Pietrzik Cu, Bartsch Jw, Tholey A, Becker-pauly C
(2019) Cell Mol Life Sci  :  Icon PUBMED

2018
32.  Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1. 
Pulido D, Sharma U, Vadon-le Goff S, Hussain Sa, Cordes S, Mariano N, Bettler E, Moali C, Aghajari N, Hohenester E, Hulmes Djs
(2018) Structure  :  Icon PUBMED

31.  Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity. 
Talantikite M, Lecorche P, Beau F, Damour O, Becker-pauly C, Ho Wb, Dive V, Vadon-le Goff S, Moali C
(2018) Febs Open Bio 8 :2011-2021  Icon PUBMED

2017
30.  Deficiency of the DSPP-cleaving enzymes meprin ? and meprin ? does not result in dentin malformation in mice. 
Arnold P, Koopmann L, Peters F, Birkenfeld F, Goff Sv, Damm T, Qin C, Moali C, Lucius R, Becker-pauly C
(2017) Cell Tissue Res 367 :351-358  Icon PUBMED

29.  Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases. 
Lacroix M, Tessier A, Dumestre-perard C, Vadon-le Goff S, Gout E, Bruckner-tuderman L, Kiritsi D, Nystrom A, Ricard-blum S, Moali C, Hulmes Djs, Thielens Nm
(2017) Sci Rep 7 :16958-16958  Icon PUBMED

28.  Structural basis of homo- and heterotrimerization of collagen I. 
Sharma U, Carrique L, Vadon-le Goff S, Mariano N, Georges Rn, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes Dj
(2017) Nat Commun 8 :14671-14671  Icon PUBMED

2016
27.  Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-? signaling as primary targets. 
Bekhouche M, Leduc C, Dupont L, Janssen L, Delolme F, Vadon-le Goff S, Smargiasso N, Baiwir D, Mazzucchelli G, Zanella-cleon I, Dubail J, De Pauw E, Nusgens B, Hulmes Dj, Moali C, Colige A
(2016) Faseb J 30 :1741-56  Icon PUBMED

26.  Characterization of post-translational modifications in full-length human BMP-1 confirms the presence of a rare vicinal disulfide linkage in the catalytic domain and highlights novel features of the EGF domain. 
Hung Cw, Koudelka T, Anastasi C, Becker A, Moali C, Tholey A
(2016) J Proteomics 138 :136-45  Icon PUBMED

2015
25.  Proteolytic control of TGF-? co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics. 
Delolme F, Anastasi C, Alcaraz Lb, Mendoza V, Vadon-le Goff S, Talantikite M, Capomaccio R, Mevaere J, Fortin L, Mazzocut D, Damour O, Zanella-cleon I, Hulmes Dj, Overall Cm, Valcourt U, Lopez-casillas F, Moali C
(2015) Cell Mol Life Sci 72 :1009-27  Icon PUBMED

24.  BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling. 
Vadon-le Goff S, Hulmes Dj, Moali C
(2015) Matrix Biol 44-46 :14-23  Icon PUBMED

2014
23.  Upregulation of bone morphogenetic protein-1/mammalian tolloid and procollagen C-proteinase enhancer-1 in corneal scarring. 
Malecaze F, Massoudi D, Fournie P, Tricoire C, Cassagne M, Malbouyres M, Hulmes Dj, Moali C, Galiacy Sd
(2014) Invest Ophthalmol Vis Sci 55 :6712-21  Icon PUBMED

2013
22.  Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation. 
Bourhis Jm, Vadon-le Goff S, Afrache H, Mariano N, Kronenberg D, Thielens N, Moali C, Hulmes Dj
(2013) Proc Natl Acad Sci U S A 110 :6394-9  Icon PUBMED

21.  Metalloproteases meprin ? and meprin ? are C- and N-procollagen proteinases important for collagen assembly and tensile strength. 
Broder C, Arnold P, Vadon-le Goff S, Konerding Ma, Bahr K, Muller S, Overall Cm, Bond Js, Koudelka T, Tholey A, Hulmes Dj, Moali C, Becker-pauly C
(2013) Proc Natl Acad Sci U S A 110 :14219-24  Icon PUBMED

2012
20.  Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. 
Bijakowski C, Vadon-le Goff S, Delolme F, Bourhis Jm, Lecorche P, Ruggiero F, Becker-pauly C, Yiallouros I, Stocker W, Dive V, Hulmes Dj, Moali C
(2012) J Biol Chem 287 :33581-93  Icon PUBMED

19.  Structural basis of fibrillar collagen trimerization and related genetic disorders. 
Bourhis Jm, Mariano N, Zhao Y, Harlos K, Exposito Jy, Jones Ey, Moali C, Aghajari N, Hulmes Dj
(2012) Nat Struct Mol Biol 19 :1031-6  Icon PUBMED

18.  Production and crystallization of the C-propeptide trimer from human procollagen III. 
Bourhis Jm, Mariano N, Zhao Y, Walter Ts, El Omari K, Delolme F, Moali C, Hulmes Dj, Aghajari N
(2012) Acta Crystallogr Sect F Struct Biol Cryst Commun 68 :1209-13  Icon PUBMED

17.  Development of ex vivo organ culture models to mimic human corneal scarring. 
Janin-manificat H, Rovere Mr, Galiacy Sd, Malecaze F, Hulmes Dj, Moali C, Damour O
(2012) Mol Vis 18 :2896-908  Icon PUBMED

2011
16.  Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only. 
Vadon-le Goff S, Kronenberg D, Bourhis Jm, Bijakowski C, Raynal N, Ruggiero F, Farndale Rw, Stocker W, Hulmes Dj, Moali C
(2011) J Biol Chem 286 :38932-8  Icon PUBMED

2010
15.  Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. 
Bekhouche M, Kronenberg D, Vadon-le Goff S, Bijakowski C, Lim Nh, Font B, Kessler E, Colige A, Nagase H, Murphy G, Hulmes Dj, Moali C
(2010) J Biol Chem 285 :15950-9  Icon PUBMED

14.  Processing of procollagen III by meprins: new players in extracellular matrix assembly? 
Kronenberg D, Bruns Bc, Moali C, Vadon-le Goff S, Sterchi Ee, Traupe H, Bohm M, Hulmes Dj, Stocker W, Becker-pauly C
(2010) J Invest Dermatol 130 :2727-35  Icon PUBMED

2009
13.  Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity. 
Kronenberg D, Vadon-le Goff S, Bourhis Jm, Font B, Eichenberger D, Hulmes Dj, Moali C
(2009) J Biol Chem 284 :33437-46  Icon PUBMED

12.  Extracellular and cell surface proteases in wound healing: new players are still emerging. 
Moali C, Hulmes Dj
(2009) Eur J Dermatol 19 :552-64  Icon PUBMED

2007
11.  Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity. 
Blanc G, Font B, Eichenberger D, Moreau C, Ricard-blum S, Hulmes Dj, Moali C
(2007) J Biol Chem 282 :16924-33  Icon PUBMED

2005
10.  Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1. 
Moali C, Font B, Ruggiero F, Eichenberger D, Rousselle P, Francois V, Oldberg A, Bruckner-tuderman L, Hulmes Dj
(2005) J Biol Chem 280 :24188-94  Icon PUBMED

2003
9.  Analysis of the importance of the metallo-beta-lactamase active site loop in substrate binding and catalysis. 
Moali C, Anne C, Lamotte-brasseur J, Groslambert S, Devreese B, Van Beeumen J, Galleni M, Frere Jm
(2003) Chem Biol 10 :319-29  Icon PUBMED

2002
8.  Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1. 
Ricard-blum S, Bernocco S, Font B, Moali C, Eichenberger D, Farjanel J, Burchardt Er, Van Der Rest M, Kessler E, Hulmes Dj
(2002) J Biol Chem 277 :33864-9  Icon PUBMED

2001
7.  CENTA as a chromogenic substrate for studying beta-lactamases. 
Bebrone C, Moali C, Mahy F, Rival S, Docquier Jd, Rossolini Gm, Fastrez J, Pratt Rf, Frere Jm, Galleni M
(2001) Antimicrob Agents Chemother 45 :1868-71  Icon PUBMED

6.  Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity. 
Moali C, Boucher Jl, Renodon-corniere A, Stuehr Dj, Mansuy D
(2001) Chem Res Toxicol 14 :202-10  Icon PUBMED

5.  Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies. 
Mollard C, Moali C, Papamicael C, Damblon C, Vessilier S, Amicosante G, Schofield Cj, Galleni M, Frere Jm, Roberts Gc
(2001) J Biol Chem 276 :45015-23  Icon PUBMED

1999
4.  Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. 
Boucher Jl, Moali C, Tenu Jp
(1999) Cell Mol Life Sci 55 :1015-28  Icon PUBMED

1998
3.  Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine. 
Moali C, Boucher Jl, Sari Ma, Stuehr Dj, Mansuy D
(1998) Biochemistry 37 :10453-60  Icon PUBMED

2.  Detection of a nitric oxide synthase possibly involved in the regulation of the Rhodococcus sp R312 nitrile hydratase. 
Sari Ma, Moali C, Boucher Jl, Jaouen M, Mansuy D
(1998) Biochem Biophys Res Commun 250 :364-8  Icon PUBMED

1997
1.  Highly efficient control of iron-containing nitrile hydratases by stoichiometric amounts of nitric oxide and light. 
Bonnet D, Artaud I, Moali C, Petre D, Mansuy D
(1997) Febs Lett 409 :216-20  Icon PUBMED