Mini Curriculum Vitae

Frédéric MALLEIN-GERIN

PhotoMALLEIN-GERIN
Equipe : Biologie et ingénierie du cartilage
Courriel : frederic.mallein-gerin@ibcp.fr
Téléphone : +33(0)4-37-65-29-19
Statut : Directeur de recherches


2019
65.  Design and characterization of a chitosan-enriched fibrin hydrogel for human dental pulp regeneration. 
Ducret M, Montembault A, Josse J, Pasdeloup M, Celle A, Benchrih R, Mallein-gerin F, Alliot-licht B, David L, Farges Jc
(2019) Dent Mater 35 :523-533  Icon PUBMED

64.  Combination of bioactive factors and IEIK13 self-assembling peptide hydrogel promotes cartilage matrix production by human nasal chondrocytes. 
Dufour A, Buffier M, Vertu-ciolino D, Disant F, Mallein-gerin F, Perrier-groult E
(2019) J Biomed Mater Res A 107 :893-903  Icon PUBMED

63.  Evaluation of the biocompatibility and stability of allogeneic tissue-engineered cartilage in humanized mice. 
Perrier-groult E, Peres E, Pasdeloup M, Gazzolo L, Duc Dodon M, Mallein-gerin F
(2019) Plos One 14 :e0217183-e0217183  Icon PUBMED

2017
62.  Current challenges in human tooth revitalization. 
Ducret M, Fabre H, Celle A, Mallein-gerin F, Perrier-groult E, Alliot-licht B, Farges Jc
(2017) Biomed Mater Eng 28 :S159-S168  Icon PUBMED

61.  Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study. 
Rodriguez J, Pratta As, Abbassi N, Fabre H, Rodriguez F, Debard C, Adobati J, Boucher F, Mallein-gerin F, Auxenfans C, Damour O, Mojallal A
(2017) Stem Cells Int 2017 :9289213-9289213  Icon PUBMED

2016
60.  Immunophenotyping Reveals the Diversity of Human Dental Pulp Mesenchymal Stromal Cells In vivo and Their Evolution upon In vitro Amplification. 
Ducret M, Fabre H, Degoul O, Atzeni G, Mcguckin C, Forraz N, Mallein-gerin F, Perrier-groult E, Alliot-licht B, Farges Jc
(2016) Front Physiol 7 :512-512  Icon PUBMED

59.  Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK. 
Lafont Je, Poujade Fa, Pasdeloup M, Neyret P, Mallein-gerin F
(2016) Osteoarthritis Cartilage 24 :856-67  Icon PUBMED

58.  Interstitial Perfusion Culture with Specific Soluble Factors Inhibits Type I Collagen Production from Human Osteoarthritic Chondrocytes in Clinical-Grade Collagen Sponges. 
Mayer N, Lopa S, Talo G, Lovati Ab, Pasdeloup M, Riboldi Sa, Moretti M, Mallein-gerin F
(2016) Plos One 11 :e0161479-e0161479  Icon PUBMED

2015
57.  Manufacturing of dental pulp cell-based products from human third molars: current strategies and future investigations. 
Ducret M, Fabre H, Degoul O, Atzeni G, Mcguckin C, Forraz N, Alliot-licht B, Mallein-gerin F, Perrier-groult E, Farges Jc
(2015) Front Physiol 6 :213-213  Icon PUBMED

2014
56.  A unique tool to selectively detect the chondrogenic IIB form of human type II procollagen protein. 
Aubert-foucher E, Mayer N, Pasdeloup M, Pagnon A, Hartmann D, Mallein-gerin F
(2014) Matrix Biol 34 :80-8  Icon PUBMED

55.  Cartilage tissue engineering: molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction. 
Demoor M, Ollitrault D, Gomez-leduc T, Bouyoucef M, Hervieu M, Fabre H, Lafont J, Denoix Jm, Audigie F, Mallein-gerin F, Legendre F, Galera P
(2014) Biochim Biophys Acta 1840 :2414-40  Icon PUBMED

54.  [Reconstruction of nasal cartilage defects using a tissue engineering technique based on combination of high-density polyethylene and hydrogel]. 
Durbec M, Mayer N, Vertu-ciolino D, Disant F, Mallein-gerin F, Perrier-groult E
(2014) Pathol Biol (paris) 62 :137-45  Icon PUBMED

2013
53.  Alteration of cartilage mechanical properties in absence of ?1 integrins revealed by rheometry and FRAP analyses. 
Bougault C, Cueru L, Bariller J, Malbouyres M, Paumier A, Aszodi A, Berthier Y, Mallein-gerin F, Trunfio-sfarghiu Am
(2013) J Biomech 46 :1633-40  Icon PUBMED

52.  Mechanical and physicochemical responses for hyaline cartilage: role of protein ?1 integrin in mechanotransduction. 
Cueru L, Bougault C, Aszodi A, Berthier Y, Mallein-gerin F, Sfarghiu Am
(2013) Comput Methods Biomech Biomed Engin 16 Suppl 1 :330-1  Icon PUBMED

51.  Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia. 
Legendre F, Ollitrault D, Hervieu M, Bauge C, Maneix L, Goux D, Chajra H, Mallein-gerin F, Boumediene K, Galera P, Demoor M
(2013) Tissue Eng Part C Methods 19 :550-67  Icon PUBMED

50.  Control of collagen production in mouse chondrocytes by using a combination of bone morphogenetic protein-2 and small interfering RNA targeting Col1a1 for hydrogel-based tissue-engineered cartilage. 
Perrier-groult E, Pasdeloup M, Malbouyres M, Galera P, Mallein-gerin F
(2013) Tissue Eng Part C Methods 19 :652-64  Icon PUBMED

2012
49.  Cartilage-characteristic matrix reconstruction by sequential addition of soluble factors during expansion of human articular chondrocytes and their cultivation in collagen sponges. 
Claus S, Mayer N, Aubert-foucher E, Chajra H, Perrier-groult E, Lafont J, Piperno M, Damour O, Mallein-gerin F
(2012) Tissue Eng Part C Methods 18 :104-12  Icon PUBMED

48.  Deciphering chondrocyte behaviour in matrix-induced autologous chondrocyte implantation to undergo accurate cartilage repair with hyaline matrix. 
Demoor M, Maneix L, Ollitrault D, Legendre F, Duval E, Claus S, Mallein-gerin F, Moslemi S, Boumediene K, Galera P
(2012) Pathol Biol (paris) 60 :199-207  Icon PUBMED

47.  Increased adipogenesis in cultured embryonic chondrocytes and in adult bone marrow of dominant negative Erg transgenic mice. 
Flajollet S, Tian Tv, Huot L, Tomavo N, Flourens A, Holder-espinasse M, Le Jeune M, Dumont P, Hot D, Mallein-gerin F, Duterque-coquillaud M
(2012) Plos One 7 :e48656-e48656  Icon PUBMED

46.  Chondrocytes or adult stem cells for cartilage repair: the indisputable role of growth factors. 
Freyria Am, Mallein-gerin F
(2012) Injury 43 :259-65  Icon PUBMED

45.  Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes. 
Renard E, Poree B, Chadjichristos C, Kypriotou M, Maneix L, Bigot N, Legendre F, Ollitrault D, De Crombrugghe B, Mallein-gerin F, Moslemi S, Demoor M, Boumediene K, Galera P
(2012) J Mol Med (berl) 90 :649-66  Icon PUBMED

2011
44.  Deciphering signaling mechanisms controling chondrocyte differentiation: Application to tissue engineering of cartilage: The ANR-TecSan PROMOCART project 
Claus S, Aubert-foucher E, Perrier-groult E, Bougault C, Ronziere Mc, Freyria Am, Legendre F, Ollitrault D, Boumediene K, Demoor M, Galera P, Tian Tv, Flajollet S, Duterque-coquillaud M, Damour O, Chajra H, Mallein-gerin F
(2011) Irbm 32 :95-98

43.  THE EXPRESSION OF GRP GENE, ENCODING FOUR NEW GLA-RICH PROTEIN ISOFORMS, IS FINELY REGULATED IN CARTILAGE 
Le Jeune M, Duterque-coquillaud M, Flajollet S, Tian Ta, Legeai-mallet L, Tomavo N, Flourens A, Holder-espinasse M, Galera P, Mallein-gerin F
(2011) Osteoporosis International 22 :52-53

42.  Analysis of collagen expression during chondrogenic induction of human bone marrow mesenchymal stem cells. 
Perrier E, Ronziere Mc, Bareille R, Pinzano A, Mallein-gerin F, Freyria Am
(2011) Biotechnol Lett 33 :2091-101  Icon PUBMED

2010
41.  Chronic exposure of bone morphogenetic protein-2 favors chondrogenic expression in human articular chondrocytes amplified in monolayer cultures. 
Claus S, Aubert-foucher E, Demoor M, Camuzeaux B, Paumier A, Piperno M, Damour O, Duterque-coquillaud M, Galera P, Mallein-gerin F
(2010) J Cell Biochem 111 :1642-51  Icon PUBMED

40.  BONE MORPHOGENETIC PROTEIN-2 IS A SPECIFIC CHONDROGENIC INDUCER WITH POTENTIAL USE FOR (MATRIX-ASSOCIATED) AUTOLOGOUS CHONDROCYTE IMPLANTATION 
Claus S, Aubert-foucher E, Demoor M, Chajra H, Mayer N, Damour O, Galera P, Mallein-gerin F
(2010) Osteoarthritis And Cartilage 18 :S116-S116

39.  BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes. 
Gouttenoire J, Bougault C, Aubert-foucher E, Perrier E, Ronziere Mc, Sandell L, Lundgren-akerlund E, Mallein-gerin F
(2010) Eur J Cell Biol 89 :307-14  Icon PUBMED

38.  Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein. 
Le Jeune M, Tomavo N, Tian Tv, Flourens A, Marchand N, Camuzeaux B, Mallein-gerin F, Duterque-coquillaud M
(2010) Exp Cell Res 316 :203-15  Icon PUBMED

37.  BMP-2, HYPOXIA, COLLAGEN SPONGES AND PARTICULAR INHIBITORS: AN INNOVATIVE COMBINATION FOR THE RECOVERY OF HUMAN CHONDROCYTE PHENOTYPE. APPLICATIONS FOR THE CELL THERAPY OF ARTICULAR CARTILAGE 
Ollitrault D, Legendre F, Hervieu M, Bauge C, Maneix L, Renard E, Goux D, Leclercq S, Chajra H, Mallein-gerin F, Boumediene K, Demoor M, Galera P
(2010) Osteoarthritis And Cartilage 18 :S82-S82

2009
36.  Molecular responses of chondrocytes cultured in agarose to dynamic compression 
Bougault C, Paumier A, Aszodi A, Aubert-foucher E, Mallein-gerin F
(2009) International Journal Of Experimental Pathology 90 :A101-A101

35.  Investigating conversion of mechanical force into biochemical signaling in three-dimensional chondrocyte cultures. 
Bougault C, Paumier A, Aubert-foucher E, Mallein-gerin F
(2009) Nat Protoc 4 :928-38  Icon PUBMED

34.  Comparative phenotypic analysis of articular chondrocytes cultured within type I or type II collagen scaffolds. 
Freyria Am, Ronziere Mc, Cortial D, Galois L, Hartmann D, Herbage D, Mallein-gerin F
(2009) Tissue Eng Part A 15 :1233-45  Icon PUBMED

33.  [Human chondrocyte responsiveness to bone morphogenetic protein-2 after their in vitro dedifferentiation: potential use of bone morphogenetic protein-2 for cartilage cell therapy]. 
Salentey V, Claus S, Bougault C, Paumier A, Aubert-foucher E, Perrier-groult E, Ronziere Mc, Freyria Am, Galera P, Beauchef G, Duterque-coquillaud M, Piperno M, Damour O, Herbage B, Mallein-gerin F
(2009) Pathol Biol (paris) 57 :282-9  Icon PUBMED

32.  Stable subclones of the chondrogenic murine cell line MC615 mimic distinct stages of chondrocyte differentiation. 
Surmann-schmitt C, Widmann N, Mallein-gerin F, Von Der Mark K, Stock M
(2009) J Cell Biochem 108 :589-99  Icon PUBMED

2008
31.  Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression. 
Bougault C, Paumier A, Aubert-foucher E, Mallein-gerin F
(2008) Bmc Biotechnol 8 :71-71  Icon PUBMED

30.  Collagen-based biomaterials and cartilage engineering. Application to osteochondral defects. 
Chajra H, Rousseau Cf, Cortial D, Ronziere Mc, Herbage D, Mallein-gerin F, Freyria Am
(2008) Biomed Mater Eng 18 :S33-45  Icon PUBMED

29.  [Differentiation of adult human mesenchymal stem cells: chondrogenic effect of BMP-2]. 
Freyria Am, Courtes S, Mallein-gerin F
(2008) Pathol Biol (paris) 56 :326-33  Icon PUBMED

28.  Bone morphogenetic protein-2 stimulates chondrogenic expression in human nasal chondrocytes expanded in vitro. 
Hautier A, Salentey V, Aubert-foucher E, Bougault C, Beauchef G, Ronziere Mc, De Sobarnitsky S, Paumier A, Galera P, Piperno M, Damour O, Mallein-gerin F
(2008) Growth Factors 26 :201-11  Icon PUBMED

27.  Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter. 
Poree B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, Melin M, Gueret S, Hartmann Dj, Mallein-gerin F, Pujol Jp, Boumediene K, Galera P
(2008) J Biol Chem 283 :4850-65  Icon PUBMED

2007
26.  Influence of different collagen-based scaffolds (sponge or type I and II gels) on the phenotypic and collagenases expression of bovine chondrocytes 
Freyria Am , Ronziere Mc , Cortial D , Herbage D , Mallein-gerin F
(2007) Tissue Engineering 13 :1715-1715

25.  Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. 
Gouttenoire J, Valcourt U, Bougault C, Aubert-foucher E, Arnaud E, Giraud L, Mallein-gerin F
(2007) J Biol Chem 282 :30960-73  Icon PUBMED

2006
24.  Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis. 
Cortial D, Gouttenoire J, Rousseau Cf, Ronziere Mc, Piccardi N, Msika P, Herbage D, Mallein-gerin F, Freyria Am
(2006) Osteoarthritis Cartilage 14 :631-40  Icon PUBMED

23.  [Biomaterials and cell therapy in cartilage disorders]. 
Herbage D, Chajra H, Galois L, Freyria Am, Mallein-gerin F
(2006) Bull Acad Natl Med 190 :1399-1408  Icon PUBMED

22.  Thyroid hormone-stimulated differentiation of primary rib chondrocytes in vitro requires thyroid hormone receptor beta. 
Rabier B, Williams Aj, Mallein-gerin F, Williams Gr, Chassande O
(2006) J Endocrinol 191 :221-8  Icon PUBMED

21.  A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes. 
Ulivi V, Tutolo G, Mallein-gerin F, Daga A, Cancedda R, Cancedda Fd
(2006) J Cell Physiol 206 :728-37  Icon PUBMED

2005
20.  Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation. 
Gomez C, Burt-pichat B, Mallein-gerin F, Merle B, Delmas Pd, Skerry Tm, Vico L, Malaval L, Chenu C
(2005) Dev Dyn 234 :393-403  Icon PUBMED

19.  Integrin alpha1beta1 mediates collagen induction of MMP-13 expression in MC615 chondrocytes. 
Ronziere Mc, Aubert-foucher E, Gouttenoire J, Bernaud J, Herbage D, Mallein-gerin F
(2005) Biochim Biophys Acta 1746 :55-64  Icon PUBMED

2004
18.  Modulation of collagen synthesis in normal and osteoarthritic cartilage. 
Gouttenoire J, Valcourt U, Ronziere Mc, Aubert-foucher E, Mallein-gerin F, Herbage D
(2004) Biorheology 41 :535-42  Icon PUBMED

17.  Gene expression analysis in cartilage by in situ hybridization. 
Mallein-gerin F, Gouttenoire J
(2004) Methods Mol Med 100 :105-8  Icon PUBMED

16.  RNA extraction from cartilage. 
Mallein-gerin F, Gouttenoire J
(2004) Methods Mol Med 100 :101-4  Icon PUBMED

2003
15.  Keratinocyte motility induced by TGF-beta1 is accompanied by dramatic changes in cellular interactions with laminin 5. 
Decline F, Okamoto O, Mallein-gerin F, Helbert B, Bernaud J, Rigal D, Rousselle P
(2003) Cell Motil Cytoskeleton 54 :64-80  Icon PUBMED

2002
14.  Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes. 
Valcourt U, Gouttenoire J, Moustakas A, Herbage D, Mallein-gerin F
(2002) J Biol Chem 277 :33545-58  Icon PUBMED

13.  Differential effects of osteogenic protein-1 (BMP-7) on gene expression of BMP and GDF family members during differentiation of the mouse MC615 chondrocyte cells. 
Yeh Lc, Mallein-gerin F, Lee Jc
(2002) J Cell Physiol 191 :298-309  Icon PUBMED

2001
12.  Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis. 
Bluteau G, Conrozier T, Mathieu P, Vignon E, Herbage D, Mallein-gerin F
(2001) Biochim Biophys Acta 1526 :147-58  Icon PUBMED

1999
11.  Different effects of bone morphogenetic proteins 2, 4, 12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line. 
Valcourt U, Ronziere Mc, Winkler P, Rosen V, Herbage D, Mallein-gerin F
(1999) Exp Cell Res 251 :264-74  Icon PUBMED

1996
10.  Analysis of the chondrocyte phenotype in culture  
Malleingerin F, Vanderrest M
(1996) M S-medecine Sciences  12 :1087-1096

1994
9.  Localization of the expression of type I, II and III collagen genes in human normal and hypochondrogenesis cartilage canals. 
Le Guellec D, Mallein-gerin F, Treilleux I, Bonaventure J, Peysson P, Herbage D
(1994) Histochem J 26 :695-704  Icon PUBMED

1993
8.  Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype. 
Mallein-gerin F, Olsen Br
(1993) Proc Natl Acad Sci U S A 90 :3289-93  Icon PUBMED

7.  IDENTIFICATION AND LOCALIZATION OF FRANKIA STRAINS IN ALNUS NODULES BY INSITU HYBRIDIZATION OF NIF-H MESSENGER-RNA WITH STRAIN-SPECIFIC OLIGONUCLEOTIDE PROBES  
Prin Y, Malleingerin F, Simonet P
(1993) Journal Of Experimental Botany  44 :815-820

1991
6.  [Detection of mRNA by in situ hybridization in tissues fixed in Bouin’s fixative and embedded in paraffin]. 
Treilleux I, Mallein-gerin F, Le Guellec D, Bouvier R, Berger F, Herbage D
(1991) Ann Pathol 11 :47-53  Icon PUBMED

1990
5.  Tendon collagen fibrillogenesis is a multistep assembly process as revealed by quick-freezing and freeze-substitution. 
Mallein-gerin F, Garrone R
(1990) Biol Cell 69 :9-16  Icon PUBMED

4.  Proteoglycan core protein and type II collagen gene expressions are not correlated with cell shape changes during low density chondrocyte cultures. 
Mallein-gerin F, Ruggiero F, Garrone R
(1990) Differentiation 43 :204-11  Icon PUBMED

3.  SUBEPITHELIAL TYPE-II COLLAGEN DEPOSITION DURING EMBRYONIC CHICK LIMB DEVELOPMENT  
Malleingerin F
(1990) Rouxs Archives Of Developmental Biology  198 :363-369

1988
2.  Temporal and spatial analysis of cartilage proteoglycan core protein gene expression during limb development by in situ hybridization. 
Mallein-gerin F, Kosher Ra, Upholt Wb, Tanzer Ml
(1988) Dev Biol 126 :337-45  Icon PUBMED

1986
1.  PRESERVATION OF POLYGONAL SECTIONS AND INTERNAL DOMAINS BY QUICK-FREEZING OF COLLAGEN FIBRILS  
Malleingerin F, Garrone R
(1986) International Journal Of Biological Macromolecules  8 :121-123