Mini Curriculum Vitae


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Statut : Ingénieur d’études

27.  Lysine-tagged peptide coupling onto polylactide nanoparticles coated with activated ester-based amphiphilic copolymer: a route to highly peptide-functionalized biodegradable carriers. 
Handke N, Ficheux D, Rollet M, Delair T, Mabrouk K, Bertin D, Gigmes D, Verrier B, Trimaille T
(2013) Colloids Surf B Biointerfaces 103 :298-303  Icon PUBMED

26.  A synthetic peptide derived from the parasite Toxoplasma gondii triggers human dendritic cells’ migration. 
Persat F, Mercier C, Ficheux D, Colomb E, Trouillet S, Bendridi N, Musset K, Loeuillet C, Cesbron-delauw Mf, Vincent C
(2012) J Leukoc Biol 92 :1241-50  Icon PUBMED

25.  First hyperpolarizability of the natural aromatic amino acids tryptophan, tyrosine, and phenylalanine and the tripeptide lysine-tryptophan-lysine determined by hyper-Rayleigh scattering. 
Duboisset J, Matar G, Russier-antoine I, Benichou E, Bachelier G, Jonin Ch, Ficheux D, Besson F, Brevet Pf
(2010) J Phys Chem B 114 :13861-5  Icon PUBMED

24.  Second Harmonic Generation, a new approach for analyzing the interfacial properties of a short tryptophan-rich peptide 
Matar G, Duboisset J, Benichou E, Bachelier G, Russier-antoine I, Jonin C, Ficheux D, Brevet Pf, Besson F
(2010) Chemical Physics Letters 500 :161-166

23.  Structural requirements for nucleocapsid protein-mediated dimerization of avian leukosis virus RNA. 
Ali Mb, Chaminade F, Kanevsky I, Ennifar E, Josset L, Ficheux D, Darlix Jl, Fosse P
(2007) J Mol Biol 372 :1082-96  Icon PUBMED

22.  The single-finger nucleocapsid protein of moloney murine leukemia virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealing. 
Egele C, Piemont E, Didier P, Ficheux D, Roques B, Darlix Jl, De Rocquigny H, Mely Y
(2007) Biochemistry 46 :14650-62  Icon PUBMED

21.  Investigating the mechanism of the nucleocapsid protein chaperoning of the second strand transfer during HIV-1 DNA synthesis. 
Ramalanjaona N, De Rocquigny H, Millet A, Ficheux D, Darlix Jl, Mely Y
(2007) J Mol Biol 374 :1041-53  Icon PUBMED

20.  A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein  
Raja C, Ferner J, Dietrich U, Avilov S, Ficheux D, Darlix Jl, De Rocquigny H, Schwalbe H, Mely Y
(2006) Biochemistry  45 :9254-9265

19.  Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis. 
Beltz H, Clauss C, Piemont E, Ficheux D, Gorelick Rj, Roques B, Gabus C, Darlix Jl, De Rocquigny H, Mely Y
(2005) J Mol Biol 348 :1113-26  Icon PUBMED

18.  Specific interactions between HIV-1 nucleocapsid protein and the TAR element. 
Kanevsky I, Chaminade F, Ficheux D, Moumen A, Gorelick R, Negroni M, Darlix Jl, Fosse P
(2005) J Mol Biol 348 :1059-77  Icon PUBMED

17.  Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7. 
Beltz H, Piemont E, Schaub E, Ficheux D, Roques B, Darlix Jl, Mely Y
(2004) J Mol Biol 338 :711-23  Icon PUBMED

16.  Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7. 
Beltz H, Azoulay J, Bernacchi S, Clamme Jp, Ficheux D, Roques B, Darlix Jl, Mely Y
(2003) J Mol Biol 328 :95-108  Icon PUBMED

15.  Alpha-helical coiled-coil oligomerization domains are almost ubiquitous in the collagen superfamily. 
Mcalinden A, Smith Ta, Sandell Lj, Ficheux D, Parry Da, Hulmes Dj
(2003) J Biol Chem 278 :42200-7  Icon PUBMED

14.  Analysis of NCp7-dependent activation of HIV-1 cDNA integration and its conservation among retroviral nucleocapsid proteins. 
Poljak L, Batson Sm, Ficheux D, Roques Bp, Darlix Jl, Kas E
(2003) J Mol Biol 329 :411-21  Icon PUBMED

13.  HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence. 
Bernacchi S, Stoylov S, Piemont E, Ficheux D, Roques Bp, Darlix Jl, Mely Y
(2002) J Mol Biol 317 :385-99  Icon PUBMED

12.  The GAG-like protein of the yeast Ty1 retrotransposon contains a nucleic acid chaperone domain analogous to retroviral nucleocapsid proteins. 
Cristofari G, Ficheux D, Darlix Jl
(2000) J Biol Chem 275 :19210-7  Icon PUBMED

11.  Characterization of active reverse transcriptase and nucleoprotein complexes of the yeast retrotransposon Ty3 in vitro. 
Cristofari G, Gabus C, Ficheux D, Bona M, Le Grice Sf, Darlix Jl
(1999) J Biol Chem 274 :36643-8  Icon PUBMED

10.  Aggregation of mononucleated precursors triggers cell surface expression of alphavbeta3 integrin, essential to formation of osteoclast-like multinucleated cells. 
Boissy P, Machuca I, Pfaff M, Ficheux D, Jurdic P
(1998) J Cell Sci 111 ( Pt 17) :2563-74  Icon PUBMED

9.  The yeast Ty3 retrotransposon contains a 5′-3′ bipartite primer-binding site and encodes nucleocapsid protein NCp9 functionally homologous to HIV-1 NCp7. 
Gabus C, Ficheux D, Rau M, Keith G, Sandmeyer S, Darlix Jl
(1998) Embo J 17 :4873-80  Icon PUBMED

8.  Possible roles of nucleocapsid protein of MoMuLV in the specificity of proviral DNA synthesis and in the genetic variability of the virus. 
Rascle Jb, Ficheux D, Darlix Jl
(1998) J Mol Biol 280 :215-25  Icon PUBMED

7.  Solid-phase synthesis, conformational analysis and in vitro cleavage of synthetic human synaptobrevin II 1-93 by tetanus toxin L chain. 
Cornille F, Goudreau N, Ficheux D, Niemann H, Roques Bp
(1994) Eur J Biochem 222 :173-81  Icon PUBMED

6.  Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity. 
De Rocquigny H, Ficheux D, Gabus C, Allain B, Fournie-zaluski Mc, Darlix Jl, Roques Bp
(1993) Nucleic Acids Res 21 :823-9  Icon PUBMED

5.  Solid phase synthesis of peptides containing the non-hydrolysable analog of (O)phosphotyrosine, p(CH2PO3H2)Phe. Application to the synthesis of 344-357 sequences of the beta 2 adrenergic receptor. 
Garbay-jaureguiberry C, Ficheux D, Roques Bp
(1992) Int J Pept Protein Res 39 :523-7  Icon PUBMED

4.  A 94-kDa protein, identified as neutral endopeptidase-24.11, can inactivate atrial natriuretic peptide in the vascular endothelium. 
Soleilhac Jm, Lucas E, Beaumont A, Turcaud S, Michel Jb, Ficheux D, Fournie-zaluski Mc, Roques Bp
(1992) Mol Pharmacol 41 :609-14  Icon PUBMED

3.  First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form. 
De Rocquigny H, Ficheux D, Gabus C, Fournie-zaluski Mc, Darlix Jl, Roques Bp
(1991) Biochem Biophys Res Commun 180 :1010-8  Icon PUBMED

2.  Solid phase synthesis of a fully active analogue of cholecystokinin using the acid-stable Boc-Phe (p-CH2) SO3H as a substitute for Boc-Tyr(SO3H) in CCK8. 
Gonzalez-muniz R, Cornille F, Bergeron F, Ficheux D, Pothier J, Durieux C, Roques Bp
(1991) Int J Pept Protein Res 37 :331-40  Icon PUBMED

1.  Solid phase synthesis of the retroviral nucleocapsid protein NCp10 of Moloney murine leukaemia virus and related zinc-fingers in free SH forms. Influence of zinc chelation on structural and biochemical properties. 
Cornille F, Mely Y, Ficheux D, Savignol I, Gerard D, Darlix Jl, Fournie-zaluski Mc, Roques Bp
(1990) Int J Pept Protein Res 36 :551-8