Sandrine VADON-LE GOFF
Ingénieure Chimiste ESPCI-ParisTech
Doctorat de Chimie Bioorganique (Université Pierre et Marie Curie – Paris VI)
Précédents laboratoires :
- Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Paris V (1992-95 et 1997-2005)
- Centre de Recherche Rhodia, Saint Fons (1996-97)
Mots clés : Métalloprotéases, Activateurs, Inhibiteurs, Cibles thérapeutiques, Matrice Extracellulaire, Fibroses.
Equipe : Métalloprotéases et Remodelage tissulaire
Courriel : sandrine.legoff@ibcp.fr
Téléphone : +33(0)4-72-72-26-67
Statut : Chargé de recherches
29 publications au total. Seules les 5 dernières années sont affichées
2023
29. Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases.
Vadon-le Goff S, Tessier A, Napoli M, Dieryckx C, Bauer J, Dussoyer M, Lagoutte P, Peyronnel C, Essayan L, Kleiser S, Tueni N, Bettler E, Mariano N, Errazuriz-cerda E, Fruchart Gaillard C, Ruggiero F, Becker-pauly C, Allain Jm, Bruckner-tuderman L, Nyström A, Moali C
(2023) Nat Commun 14 :8020-8020
2022
28. Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1).
Sharma U, Vadon-le Goff S, Harlos K, Zhao Y, Mariano N, Bijakowski C, Bourhis Jm, Moali C, Hulmes Djs, Aghajari N
(2022) Sci Rep 12 :14850-14850
2021
27. Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis.
Lagoutte P, Bettler E, Vadon-le Goff S, Moali C
(2021) Matrix Biol Plus 11 :100062-100062
2018
26. Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1.
Pulido D, Sharma U, Vadon-le Goff S, Hussain Sa, Cordes S, Mariano N, Bettler E, Moali C, Aghajari N, Hohenester E, Hulmes Djs
(2018) Structure :
25. Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity.
Talantikite M, Lecorche P, Beau F, Damour O, Becker-pauly C, Ho Wb, Dive V, Vadon-le Goff S, Moali C
(2018) Febs Open Bio 8 :2011-2021
2017
24. Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases.
Lacroix M, Tessier A, Dumestre-perard C, Vadon-le Goff S, Gout E, Bruckner-tuderman L, Kiritsi D, Nystrom A, Ricard-blum S, Moali C, Hulmes Djs, Thielens Nm
(2017) Sci Rep 7 :16958-16958
23. Structural basis of homo- and heterotrimerization of collagen I.
Sharma U, Carrique L, Vadon-le Goff S, Mariano N, Georges Rn, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes Dj
(2017) Nat Commun 8 :14671-14671
2016
22. Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-? signaling as primary targets.
Bekhouche M, Leduc C, Dupont L, Janssen L, Delolme F, Vadon-le Goff S, Smargiasso N, Baiwir D, Mazzucchelli G, Zanella-cleon I, Dubail J, De Pauw E, Nusgens B, Hulmes Dj, Moali C, Colige A
(2016) Faseb J 30 :1741-56
2015
21. Proteolytic control of TGF-? co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics.
Delolme F, Anastasi C, Alcaraz Lb, Mendoza V, Vadon-le Goff S, Talantikite M, Capomaccio R, Mevaere J, Fortin L, Mazzocut D, Damour O, Zanella-cleon I, Hulmes Dj, Overall Cm, Valcourt U, Lopez-casillas F, Moali C
(2015) Cell Mol Life Sci 72 :1009-27
20. BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling.
Vadon-le Goff S, Hulmes Dj, Moali C
(2015) Matrix Biol 44-46 :14-23
2013
19. Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation.
Bourhis Jm, Vadon-le Goff S, Afrache H, Mariano N, Kronenberg D, Thielens N, Moali C, Hulmes Dj
(2013) Proc Natl Acad Sci U S A 110 :6394-9
18. Metalloproteases meprin ? and meprin ? are C- and N-procollagen proteinases important for collagen assembly and tensile strength.
Broder C, Arnold P, Vadon-le Goff S, Konerding Ma, Bahr K, Muller S, Overall Cm, Bond Js, Koudelka T, Tholey A, Hulmes Dj, Moali C, Becker-pauly C
(2013) Proc Natl Acad Sci U S A 110 :14219-24
2012
17. Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
Bijakowski C, Vadon-le Goff S, Delolme F, Bourhis Jm, Lecorche P, Ruggiero F, Becker-pauly C, Yiallouros I, Stocker W, Dive V, Hulmes Dj, Moali C
(2012) J Biol Chem 287 :33581-93
2011
16. Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only.
Vadon-le Goff S, Kronenberg D, Bourhis Jm, Bijakowski C, Raynal N, Ruggiero F, Farndale Rw, Stocker W, Hulmes Dj, Moali C
(2011) J Biol Chem 286 :38932-8
2010
15. Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.
Bekhouche M, Kronenberg D, Vadon-le Goff S, Bijakowski C, Lim Nh, Font B, Kessler E, Colige A, Nagase H, Murphy G, Hulmes Dj, Moali C
(2010) J Biol Chem 285 :15950-9
14. Processing of procollagen III by meprins: new players in extracellular matrix assembly?
Kronenberg D, Bruns Bc, Moali C, Vadon-le Goff S, Sterchi Ee, Traupe H, Bohm M, Hulmes Dj, Stocker W, Becker-pauly C
(2010) J Invest Dermatol 130 :2727-35
2009
13. Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity.
Kronenberg D, Vadon-le Goff S, Bourhis Jm, Font B, Eichenberger D, Hulmes Dj, Moali C
(2009) J Biol Chem 284 :33437-46
2001
12. Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.
Vadon-le Goff S, Delaforge M, Boucher Jl, Janosik M, Kraus Jp, Mansuy D
(2001) Biochem Biophys Res Commun 283 :487-92
2000
11. Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity.
Meurs H, Hamer Ma, Pethe S, Vadon-le Goff S, Boucher Jl, Zaagsma J
(2000) Br J Pharmacol 130 :1793-8
1998
10. Biosynthesis of NO: mechanism, regulation and control
Sennequier N, Vadon-le Goff S
(1998) M S-medecine Sciences 14 :1185-1195
1997
9. N-omega-OH-D,L-indospicine, a potent and selective: Inhibitor of arginase in rat and rabbit alveolar macrophages (AM phi) can promote utilization of L-arginine by nitric oxide synthase (NOS)
Hey C, Boucher Jl, Vadon S, Ketterer G, Stichnote C, Wessler I, Racke K
(1997) British Journal Of Pharmacology 120 :P48-P48
8. Inhibition of arginase in rat and rabbit alveolar macrophages by N omega-hydroxy-D,L-indospicine, effects on L-arginine utilization by nitric oxide synthase.
Hey C, Boucher Jl, Vadon-le Goff S, Ketterer G, Wessler I, Racke K
(1997) Br J Pharmacol 121 :395-400
1996
7. Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand.
Sari Ma, Booker S, Jaouen M, Vadon S, Boucher Ji, Pompon D, Mansuy D
(1996) Biochemistry 35 :7204-13
6. Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of N omega-hydroxyarginine, N omega-hydroxyindospicine and p-hydroxyamidinophenylalanine
Vadon S, Custot J, Boucher Jl, Mansuy D
(1996) Journal Of The Chemical Society-perkin Transactions 1 :645-648
1994
5. N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.
Boucher Jl, Custot J, Vadon S, Delaforge M, Lepoivre M, Tenu Jp, Yapo A, Mansuy D
(1994) Biochem Biophys Res Commun 203 :1614-21
4. N-OMEGA-HYDROXY-L-ARGININE, AN INTERMEDIATE IN THE L-ARGININE TO NITRIC-OXIDE PATHWAY, IS A STRONG INHIBITOR OF LIVER AND MACROPHAGE ARGINASE
Boucher Jl, Custot J, Vadon S, Delaforge M, Lepoivre M, Tenu Jp, Yapo A, Mansuy D
(1994) Biochemical And Biophysical Research Communications 203 :1614-1621
1993
3. Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.
Renaud Jp, Boucher Jl, Vadon S, Delaforge M, Mansuy D
(1993) Biochem Biophys Res Commun 192 :53-60
1992
2. Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline.
Boucher Jl, Genet A, Vadon S, Delaforge M, Henry Y, Mansuy D
(1992) Biochem Biophys Res Commun 187 :880-6
1. Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins.
Boucher Jl, Genet A, Vadon S, Delaforge M, Mansuy D
(1992) Biochem Biophys Res Commun 184 :1158-64
