Sandrine VADON-LE GOFF
Ingénieure Chimiste ESPCI-ParisTech
Doctorat de Chimie Bioorganique (Université Pierre et Marie Curie – Paris VI)
Précédents laboratoires :
- Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Paris V (1992-95 et 1997-2005)
- Centre de Recherche Rhodia, Saint Fons (1996-97)
Mots clés : Métalloprotéases, Activateurs, Inhibiteurs, Cibles thérapeutiques, Matrice Extracellulaire, Fibroses.
Equipe : Métalloprotéases et Remodelage tissulaire
Courriel : sandrine.vadon-le-goff@cnrs.fr
Téléphone : +33(0)4-72-72-26-67
Statut : Chargé de recherches
32 publications au total. Seules les 5 dernières années sont affichées
2024
32. Mono- and Bi-specific Nanobodies Targeting the CUB Domains of PCPE-1 Reduce the Proteolytic Processing of Fibrillar Procollagens.
Lagoutte P, Bourhis Jm, Mariano N, Gueguen-chaignon V, Vandroux D, Moali C, Vadon-le Goff S
(2024) J Mol Biol 436 :168667-168667
31. PCPE-2 (procollagen C-proteinase enhancer-2): The non-identical twin of PCPE-1.
Napoli M, Bauer J, Bonod C, Vadon-le Goff S, Moali C
(2024) Matrix Biol 134 :59-78
2023
30. Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system.
Blanc M, Lettl C, Guérin J, Vieille A, Furler S, Briand-schumacher S, Dreier B, Bergé C, Plückthun A, Vadon-le Goff S, Fronzes R, Rousselle P, Fischer W, Terradot L
(2023) Plos Pathog 19 :e1011368-e1011368
29. Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases.
Vadon-le Goff S, Tessier A, Napoli M, Dieryckx C, Bauer J, Dussoyer M, Lagoutte P, Peyronnel C, Essayan L, Kleiser S, Tueni N, Bettler E, Mariano N, Errazuriz-cerda E, Fruchart Gaillard C, Ruggiero F, Becker-pauly C, Allain Jm, Bruckner-tuderman L, Nyström A, Moali C
(2023) Nat Commun 14 :8020-8020
2022
28. Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1).
Sharma U, Vadon-le Goff S, Harlos K, Zhao Y, Mariano N, Bijakowski C, Bourhis Jm, Moali C, Hulmes Djs, Aghajari N
(2022) Sci Rep 12 :14850-14850
2021
27. Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis.
Lagoutte P, Bettler E, Vadon-le Goff S, Moali C
(2021) Matrix Biol Plus 11 :100062-100062
2018
26. Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1.
Pulido D, Sharma U, Vadon-le Goff S, Hussain Sa, Cordes S, Mariano N, Bettler E, Moali C, Aghajari N, Hohenester E, Hulmes Djs
(2018) Structure :
25. Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity.
Talantikite M, Lecorche P, Beau F, Damour O, Becker-pauly C, Ho Wb, Dive V, Vadon-le Goff S, Moali C
(2018) Febs Open Bio 8 :2011-2021
2017
24. Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases.
Lacroix M, Tessier A, Dumestre-perard C, Vadon-le Goff S, Gout E, Bruckner-tuderman L, Kiritsi D, Nystrom A, Ricard-blum S, Moali C, Hulmes Djs, Thielens Nm
(2017) Sci Rep 7 :16958-16958
23. Structural basis of homo- and heterotrimerization of collagen I.
Sharma U, Carrique L, Vadon-le Goff S, Mariano N, Georges Rn, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes Dj
(2017) Nat Commun 8 :14671-14671
2016
22. Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-? signaling as primary targets.
Bekhouche M, Leduc C, Dupont L, Janssen L, Delolme F, Vadon-le Goff S, Smargiasso N, Baiwir D, Mazzucchelli G, Zanella-cleon I, Dubail J, De Pauw E, Nusgens B, Hulmes Dj, Moali C, Colige A
(2016) Faseb J 30 :1741-56
2015
21. Proteolytic control of TGF-? co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics.
Delolme F, Anastasi C, Alcaraz Lb, Mendoza V, Vadon-le Goff S, Talantikite M, Capomaccio R, Mevaere J, Fortin L, Mazzocut D, Damour O, Zanella-cleon I, Hulmes Dj, Overall Cm, Valcourt U, Lopez-casillas F, Moali C
(2015) Cell Mol Life Sci 72 :1009-27
20. BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling.
Vadon-le Goff S, Hulmes Dj, Moali C
(2015) Matrix Biol 44-46 :14-23
2013
19. Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation.
Bourhis Jm, Vadon-le Goff S, Afrache H, Mariano N, Kronenberg D, Thielens N, Moali C, Hulmes Dj
(2013) Proc Natl Acad Sci U S A 110 :6394-9
18. Metalloproteases meprin ? and meprin ? are C- and N-procollagen proteinases important for collagen assembly and tensile strength.
Broder C, Arnold P, Vadon-le Goff S, Konerding Ma, Bahr K, Muller S, Overall Cm, Bond Js, Koudelka T, Tholey A, Hulmes Dj, Moali C, Becker-pauly C
(2013) Proc Natl Acad Sci U S A 110 :14219-24
2012
17. Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
Bijakowski C, Vadon-le Goff S, Delolme F, Bourhis Jm, Lecorche P, Ruggiero F, Becker-pauly C, Yiallouros I, Stocker W, Dive V, Hulmes Dj, Moali C
(2012) J Biol Chem 287 :33581-93
2011
16. Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only.
Vadon-le Goff S, Kronenberg D, Bourhis Jm, Bijakowski C, Raynal N, Ruggiero F, Farndale Rw, Stocker W, Hulmes Dj, Moali C
(2011) J Biol Chem 286 :38932-8
2010
15. Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.
Bekhouche M, Kronenberg D, Vadon-le Goff S, Bijakowski C, Lim Nh, Font B, Kessler E, Colige A, Nagase H, Murphy G, Hulmes Dj, Moali C
(2010) J Biol Chem 285 :15950-9
14. Processing of procollagen III by meprins: new players in extracellular matrix assembly?
Kronenberg D, Bruns Bc, Moali C, Vadon-le Goff S, Sterchi Ee, Traupe H, Bohm M, Hulmes Dj, Stocker W, Becker-pauly C
(2010) J Invest Dermatol 130 :2727-35
2009
13. Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity.
Kronenberg D, Vadon-le Goff S, Bourhis Jm, Font B, Eichenberger D, Hulmes Dj, Moali C
(2009) J Biol Chem 284 :33437-46
2001
12. Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.
Vadon-le Goff S, Delaforge M, Boucher Jl, Janosik M, Kraus Jp, Mansuy D
(2001) Biochem Biophys Res Commun 283 :487-92
2000
11. Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity.
Meurs H, Hamer Ma, Pethe S, Vadon-le Goff S, Boucher Jl, Zaagsma J
(2000) Br J Pharmacol 130 :1793-8
1998
10. Biosynthesis of NO: mechanism, regulation and control
Sennequier N, Vadon-le Goff S
(1998) M S-medecine Sciences 14 :1185-1195
1997
9. N-omega-OH-D,L-indospicine, a potent and selective: Inhibitor of arginase in rat and rabbit alveolar macrophages (AM phi) can promote utilization of L-arginine by nitric oxide synthase (NOS)
Hey C, Boucher Jl, Vadon S, Ketterer G, Stichnote C, Wessler I, Racke K
(1997) British Journal Of Pharmacology 120 :P48-P48
8. Inhibition of arginase in rat and rabbit alveolar macrophages by N omega-hydroxy-D,L-indospicine, effects on L-arginine utilization by nitric oxide synthase.
Hey C, Boucher Jl, Vadon-le Goff S, Ketterer G, Wessler I, Racke K
(1997) Br J Pharmacol 121 :395-400
1996
7. Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand.
Sari Ma, Booker S, Jaouen M, Vadon S, Boucher Ji, Pompon D, Mansuy D
(1996) Biochemistry 35 :7204-13
6. Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of N omega-hydroxyarginine, N omega-hydroxyindospicine and p-hydroxyamidinophenylalanine
Vadon S, Custot J, Boucher Jl, Mansuy D
(1996) Journal Of The Chemical Society-perkin Transactions 1 :645-648
1994
5. N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.
Boucher Jl, Custot J, Vadon S, Delaforge M, Lepoivre M, Tenu Jp, Yapo A, Mansuy D
(1994) Biochem Biophys Res Commun 203 :1614-21
4. N-OMEGA-HYDROXY-L-ARGININE, AN INTERMEDIATE IN THE L-ARGININE TO NITRIC-OXIDE PATHWAY, IS A STRONG INHIBITOR OF LIVER AND MACROPHAGE ARGINASE
Boucher Jl, Custot J, Vadon S, Delaforge M, Lepoivre M, Tenu Jp, Yapo A, Mansuy D
(1994) Biochemical And Biophysical Research Communications 203 :1614-1621
1993
3. Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s.
Renaud Jp, Boucher Jl, Vadon S, Delaforge M, Mansuy D
(1993) Biochem Biophys Res Commun 192 :53-60
1992
2. Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline.
Boucher Jl, Genet A, Vadon S, Delaforge M, Henry Y, Mansuy D
(1992) Biochem Biophys Res Commun 187 :880-6
1. Formation of nitrogen oxides and citrulline upon oxidation of N omega-hydroxy-L-arginine by hemeproteins.
Boucher Jl, Genet A, Vadon S, Delaforge M, Mansuy D
(1992) Biochem Biophys Res Commun 184 :1158-64
