{"id":169,"date":"2016-12-07T10:37:36","date_gmt":"2016-12-07T09:37:36","guid":{"rendered":"http:\/\/lbti.cnrs.fr\/?page_id=169"},"modified":"2026-03-16T17:54:07","modified_gmt":"2026-03-16T16:54:07","slug":"influence-de-larchitecture-tridimensionnelle-et-de-divers-biomateriaux-sur-le-phenotype-des-chondrocytes-2","status":"publish","type":"page","link":"https:\/\/lbti.ibcp.fr\/?page_id=169","title":{"rendered":"Utilisation des chondrocytes nasaux pour l\u2019ing\u00e9nierie tissulaire du cartilage"},"content":{"rendered":"
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Porteur de projet<\/em><\/strong>\u00a0:<\/span> Jean-Daniel Malcor<\/a><\/strong><\/h4>\n

Persf.mallein-gerin@ibcp.fronnes impliqu\u00e9es dans le projet<\/strong><\/em> : Delphine Vertu-Ciolino, Marielle Pasdeloup , Jean-Daniel Malcor, J\u00e9r\u00f4me Lafont
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La reconstruction du cartilage nasal repr\u00e9sente un d\u00e9fi clinique majeur. Les demandes de remplacement des d\u00e9fauts de cartilage nasal apr\u00e8s une r\u00e9section carcinologique, traumatique ou cong\u00e9nitale et les rhinoplasties esth\u00e9tiques sont en constante augmentation. Des options chirurgicales actuelles sont limit\u00e9es par les difficult\u00e9s d\u2019obtention d\u2019une quantit\u00e9 suffisante de cartilage sans cause de morbidit\u00e9 au niveau du site donneur, la dur\u00e9e\/complexit\u00e9 de la proc\u00e9dure chirurgicale et le risque d\u2019infection.<\/p>\n

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Nous avons donc fabriqu\u00e9 une cloison nasale proth\u00e9tique hautement biocompatible \u00e0 partir d\u2019un biomat\u00e9riau poreux non r\u00e9sorbable imprim\u00e9 en 3D enrob\u00e9 d\u2019un hydrogel biocompatible comportant des chondrocytes nasaux. Ceci a abouti \u00e0 la formation d\u2019un cartilage artificiel pouvant \u00eatre implant\u00e9 in vivo<\/em> pour la reconstruction du septum nasal.<\/p>\n

Les chondrocytes nasaux ont par ailleurs une capacit\u00e9 de prolif\u00e9ration plus importante, produisent un matrice extracellulaire plus dense et sont plus r\u00e9sistants aux signaux inflammatoires que les chondrocytes articulaires. Ils peuvent de plus \u00eatre pr\u00e9lev\u00e9s par biopsie du septum nasal de mani\u00e8re peu invasive, ce qui n\u2019entra\u00eene pas de morbidit\u00e9 au site donneur. Nous explorons donc \u00e9galement la reconstruction du cartilage articulaire \u00e0 partir de biomat\u00e9riaux accueillant des chondrocytes nasaux.<\/p>\n

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S\u00e9lection de publications :\u00a0<\/strong><\/em><\/span><\/p>\n<\/div>\n

1-Vertu-Ciolino D, Brunard F, Courtial EJ, Pasdeloup M, Marquette CA, Perrier-Groult E, Mallein-Gerin F, Malcor JD. (2024) Challenges in Nasal Cartilage Tissue Engineering to Restore the Shape and Function of the Nose. Tissue Eng Part B Rev<\/em><\/strong>. 2024 Dec;30(6):581-595. doi: 10.1089\/ten.TEB.2023.0326. Epub 2024 Apr 17.<\/p>\n

2-Dufour A, Lafont JE, Buffier M, Verset M, Cohendet A, Contamin H, Confais J, Sankar S, Rioult M, Perrier-Groult E, Mallein-Gerin F. (2021) Repair of full-thickness articular cartilage defects using IEIK13 self-assembling peptide hydrogel in a non-human primate model. Sci Rep<\/strong>.<\/em> Feb 25;11(1):4560. doi: 10.1038\/s41598-021-83208-x. PMID: 33633122.<\/p>\n

3- Dufour A, Buffier M, Vertu-Ciolino D, Disant F, Mallein-Gerin F, Perrier-Groult E. Combination of bioactive factors and IEIK13 self-assembling peptide hydrogel promotes cartilage matrix production by human nasal chondrocytes.<\/a> J Biomed Mater Res A<\/span>.<\/strong> 2019 Apr;107(4):893-903. doi: 10.1002\/jbm.a.36612. Epub 2019 Jan 31.<\/p>\n

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4- Durbec M, Mayer N, Vertu-Ciolino D, Disant F, Mallein-Gerin F, Perrier-Groult E. (2014)[Reconstruction of nasal cartilage defects using a tissue engineering technique based on combination of high-density polyethylene and hydrogel].<\/a>Pathol. Biol<\/em><\/strong>. 62\u00a0: 137-145.<\/span><\/p>\n

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 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Porteur de projet\u00a0: Jean-Daniel Malcor Persf.mallein-gerin@ibcp.fronnes impliqu\u00e9es dans le projet : Delphine Vertu-Ciolino, Marielle Pasdeloup , Jean-Daniel Malcor, J\u00e9r\u00f4me Lafont La reconstruction du cartilage nasal repr\u00e9sente un d\u00e9fi clinique majeur. Les demandes de remplacement des d\u00e9fauts de cartilage nasal apr\u00e8s une r\u00e9section carcinologique, traumatique ou cong\u00e9nitale et les rhinoplasties esth\u00e9tiques sont en constante augmentation. Des<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-169","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=\/wp\/v2\/pages\/169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=169"}],"version-history":[{"count":40,"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=\/wp\/v2\/pages\/169\/revisions"}],"predecessor-version":[{"id":5923,"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=\/wp\/v2\/pages\/169\/revisions\/5923"}],"wp:attachment":[{"href":"https:\/\/lbti.ibcp.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}