Frédéric MALLEIN-GERIN
Equipe : Recherche OstéoArticulaire et Dentaire
Courriel : frederic.mallein-gerin@ibcp.fr
Téléphone : +33(0)4-37-65-29-19
Statut : Directeur de recherches
74 publications au total. Seules les 5 dernières années sont affichées
2023
74. The epigenetic players and the chromatin marks involved in the articular cartilage during osteoarthritis.
Lafont Je, Moustaghfir S, Durand Al, Mallein-gerin F
(2023) Front Physiol 14 :1070241-1070241
73. Presence of type IIB procollagen in mouse articular cartilage and growth plate is revealed by immuno-histochemical analysis with a novel specific antibody.
Perrier-groult E, Moustaghfir S, Pasdeloup M, Malcor Jd, Lafont J, Mallein-gerin F
(2023) Matrix Biol Plus 18 :100130-100130
2022
72. Biomaterial functionalization with triple-helical peptides for tissue engineering.
Malcor Jd, Mallein-gerin F
(2022) Acta Biomater 148 :1-21
71. ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle.
Nordgaard C, Vind Ac, Stonadge A, Kjøbsted R, Snieckute G, Antas P, Blasius M, Reinert Ms, Del Val Am, Bekker-jensen Db, Haahr P, Miroshnikova Ya, Mazouzi A, Falk S, Perrier-groult E, Tiedje C, Li X, Jakobsen Jr, Jørgensen No, Wojtaszewski Jf, Mallein-gerin F, Andersen Jl, Pennisi Cp, Clemmensen C, Kassem M, Jafari A, Brummelkamp T, Li Vs, Wickström Sa, Olsen Jv, Blanco G, Bekker-jensen S
(2022) Embo J 41 :e111650-e111650
2021
70. Repair of full-thickness articular cartilage defects using IEIK13 self-assembling peptide hydrogel in a non-human primate model.
Dufour A, Lafont Je, Buffier M, Verset M, Cohendet A, Contamin H, Confais J, Sankar S, Rioult M, Perrier-groult E, Mallein-gerin F
(2021) Sci Rep 11 :4560-4560
2020
69. Development of an antibacterial nanocomposite hydrogel for human dental pulp engineering.
Bekhouche M, Bolon M, Charriaud F, Lamrayah M, Da Costa D, Primard C, Costantini A, Pasdeloup M, Gobert S, Mallein-gerin F, Verrier B, Ducret M, Farges Jc
(2020) J Mater Chem B 8 :8422-8432
68. The Lysine Specific Demethylase-1 Negatively Regulates the COL9A1 Gene in Human Articular Chondrocytes.
Durand Al, Dufour A, Aubert-foucher E, Oger-desfeux C, Pasdeloup M, Lustig S, Servien E, Vaz G, Perrier-groult E, Mallein-gerin F, Lafont Je
(2020) Int J Mol Sci 21 :
2019
67. Phenotypic Identification of Dental Pulp Mesenchymal Stem/Stromal Cells Subpopulations with Multiparametric Flow Cytometry.
Ducret M, Farges Jc, Pasdeloup M, Perrier-groult E, Mueller A, Mallein-gerin F, Fabre H
(2019) Methods Mol Biol 1922 :77-90
66. Design and characterization of a chitosan-enriched fibrin hydrogel for human dental pulp regeneration.
Ducret M, Montembault A, Josse J, Pasdeloup M, Celle A, Benchrih R, Mallein-gerin F, Alliot-licht B, David L, Farges Jc
(2019) Dent Mater 35 :523-533
65. Combination of bioactive factors and IEIK13 self-assembling peptide hydrogel promotes cartilage matrix production by human nasal chondrocytes.
Dufour A, Buffier M, Vertu-ciolino D, Disant F, Mallein-gerin F, Perrier-groult E
(2019) J Biomed Mater Res A 107 :893-903
64. Characterization of Different Sources of Human MSCs Expanded in Serum-Free Conditions with Quantification of Chondrogenic Induction in 3D.
Fabre H, Ducret M, Degoul O, Rodriguez J, Perrier-groult E, Aubert-foucher E, Pasdeloup M, Auxenfans C, Mcguckin C, Forraz N, Mallein-gerin F
(2019) Stem Cells Int 2019 :2186728-2186728
63. Evaluation of the biocompatibility and stability of allogeneic tissue-engineered cartilage in humanized mice.
Perrier-groult E, Peres E, Pasdeloup M, Gazzolo L, Duc Dodon M, Mallein-gerin F
(2019) Plos One 14 :e0217183-e0217183
2017
62. Current challenges in human tooth revitalization.
Ducret M, Fabre H, Celle A, Mallein-gerin F, Perrier-groult E, Alliot-licht B, Farges Jc
(2017) Biomed Mater Eng 28 :S159-S168
61. Evaluation of Three Devices for the Isolation of the Stromal Vascular Fraction from Adipose Tissue and for ASC Culture: A Comparative Study.
Rodriguez J, Pratta As, Abbassi N, Fabre H, Rodriguez F, Debard C, Adobati J, Boucher F, Mallein-gerin F, Auxenfans C, Damour O, Mojallal A
(2017) Stem Cells Int 2017 :9289213-9289213
2016
60. Immunophenotyping Reveals the Diversity of Human Dental Pulp Mesenchymal Stromal Cells In vivo and Their Evolution upon In vitro Amplification.
Ducret M, Fabre H, Degoul O, Atzeni G, Mcguckin C, Forraz N, Mallein-gerin F, Perrier-groult E, Alliot-licht B, Farges Jc
(2016) Front Physiol 7 :512-512
59. Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK.
Lafont Je, Poujade Fa, Pasdeloup M, Neyret P, Mallein-gerin F
(2016) Osteoarthritis Cartilage 24 :856-67
58. Interstitial Perfusion Culture with Specific Soluble Factors Inhibits Type I Collagen Production from Human Osteoarthritic Chondrocytes in Clinical-Grade Collagen Sponges.
Mayer N, Lopa S, Talo G, Lovati Ab, Pasdeloup M, Riboldi Sa, Moretti M, Mallein-gerin F
(2016) Plos One 11 :e0161479-e0161479
2015
57. Manufacturing of dental pulp cell-based products from human third molars: current strategies and future investigations.
Ducret M, Fabre H, Degoul O, Atzeni G, Mcguckin C, Forraz N, Alliot-licht B, Mallein-gerin F, Perrier-groult E, Farges Jc
(2015) Front Physiol 6 :213-213
2014
56. A unique tool to selectively detect the chondrogenic IIB form of human type II procollagen protein.
Aubert-foucher E, Mayer N, Pasdeloup M, Pagnon A, Hartmann D, Mallein-gerin F
(2014) Matrix Biol 34 :80-8
55. Cartilage tissue engineering: molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction.
Demoor M, Ollitrault D, Gomez-leduc T, Bouyoucef M, Hervieu M, Fabre H, Lafont J, Denoix Jm, Audigie F, Mallein-gerin F, Legendre F, Galera P
(2014) Biochim Biophys Acta 1840 :2414-40
54. [Reconstruction of nasal cartilage defects using a tissue engineering technique based on combination of high-density polyethylene and hydrogel].
Durbec M, Mayer N, Vertu-ciolino D, Disant F, Mallein-gerin F, Perrier-groult E
(2014) Pathol Biol (paris) 62 :137-45
2013
53. Alteration of cartilage mechanical properties in absence of ?1 integrins revealed by rheometry and FRAP analyses.
Bougault C, Cueru L, Bariller J, Malbouyres M, Paumier A, Aszodi A, Berthier Y, Mallein-gerin F, Trunfio-sfarghiu Am
(2013) J Biomech 46 :1633-40
52. Mechanical and physicochemical responses for hyaline cartilage: role of protein ?1 integrin in mechanotransduction.
Cueru L, Bougault C, Aszodi A, Berthier Y, Mallein-gerin F, Sfarghiu Am
(2013) Comput Methods Biomech Biomed Engin 16 Suppl 1 :330-1
51. Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia.
Legendre F, Ollitrault D, Hervieu M, Bauge C, Maneix L, Goux D, Chajra H, Mallein-gerin F, Boumediene K, Galera P, Demoor M
(2013) Tissue Eng Part C Methods 19 :550-67
50. Control of collagen production in mouse chondrocytes by using a combination of bone morphogenetic protein-2 and small interfering RNA targeting Col1a1 for hydrogel-based tissue-engineered cartilage.
Perrier-groult E, Pasdeloup M, Malbouyres M, Galera P, Mallein-gerin F
(2013) Tissue Eng Part C Methods 19 :652-64
2012
49. Cartilage-characteristic matrix reconstruction by sequential addition of soluble factors during expansion of human articular chondrocytes and their cultivation in collagen sponges.
Claus S, Mayer N, Aubert-foucher E, Chajra H, Perrier-groult E, Lafont J, Piperno M, Damour O, Mallein-gerin F
(2012) Tissue Eng Part C Methods 18 :104-12
48. Deciphering chondrocyte behaviour in matrix-induced autologous chondrocyte implantation to undergo accurate cartilage repair with hyaline matrix.
Demoor M, Maneix L, Ollitrault D, Legendre F, Duval E, Claus S, Mallein-gerin F, Moslemi S, Boumediene K, Galera P
(2012) Pathol Biol (paris) 60 :199-207
47. Increased adipogenesis in cultured embryonic chondrocytes and in adult bone marrow of dominant negative Erg transgenic mice.
Flajollet S, Tian Tv, Huot L, Tomavo N, Flourens A, Holder-espinasse M, Le Jeune M, Dumont P, Hot D, Mallein-gerin F, Duterque-coquillaud M
(2012) Plos One 7 :e48656-e48656
46. Chondrocytes or adult stem cells for cartilage repair: the indisputable role of growth factors.
Freyria Am, Mallein-gerin F
(2012) Injury 43 :259-65
45. Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.
Renard E, Poree B, Chadjichristos C, Kypriotou M, Maneix L, Bigot N, Legendre F, Ollitrault D, De Crombrugghe B, Mallein-gerin F, Moslemi S, Demoor M, Boumediene K, Galera P
(2012) J Mol Med (berl) 90 :649-66
2011
44. Deciphering signaling mechanisms controling chondrocyte differentiation: Application to tissue engineering of cartilage: The ANR-TecSan PROMOCART project
Claus S, Aubert-foucher E, Perrier-groult E, Bougault C, Ronziere Mc, Freyria Am, Legendre F, Ollitrault D, Boumediene K, Demoor M, Galera P, Tian Tv, Flajollet S, Duterque-coquillaud M, Damour O, Chajra H, Mallein-gerin F
(2011) Irbm 32 :95-98
43. THE EXPRESSION OF GRP GENE, ENCODING FOUR NEW GLA-RICH PROTEIN ISOFORMS, IS FINELY REGULATED IN CARTILAGE
Le Jeune M, Duterque-coquillaud M, Flajollet S, Tian Ta, Legeai-mallet L, Tomavo N, Flourens A, Holder-espinasse M, Galera P, Mallein-gerin F
(2011) Osteoporosis International 22 :52-53
42. Analysis of collagen expression during chondrogenic induction of human bone marrow mesenchymal stem cells.
Perrier E, Ronziere Mc, Bareille R, Pinzano A, Mallein-gerin F, Freyria Am
(2011) Biotechnol Lett 33 :2091-101
2010
41. Chronic exposure of bone morphogenetic protein-2 favors chondrogenic expression in human articular chondrocytes amplified in monolayer cultures.
Claus S, Aubert-foucher E, Demoor M, Camuzeaux B, Paumier A, Piperno M, Damour O, Duterque-coquillaud M, Galera P, Mallein-gerin F
(2010) J Cell Biochem 111 :1642-51
40. BONE MORPHOGENETIC PROTEIN-2 IS A SPECIFIC CHONDROGENIC INDUCER WITH POTENTIAL USE FOR (MATRIX-ASSOCIATED) AUTOLOGOUS CHONDROCYTE IMPLANTATION
Claus S, Aubert-foucher E, Demoor M, Chajra H, Mayer N, Damour O, Galera P, Mallein-gerin F
(2010) Osteoarthritis And Cartilage 18 :S116-S116
39. BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes.
Gouttenoire J, Bougault C, Aubert-foucher E, Perrier E, Ronziere Mc, Sandell L, Lundgren-akerlund E, Mallein-gerin F
(2010) Eur J Cell Biol 89 :307-14
38. Identification of four alternatively spliced transcripts of the Ucma/GRP gene, encoding a new Gla-containing protein.
Le Jeune M, Tomavo N, Tian Tv, Flourens A, Marchand N, Camuzeaux B, Mallein-gerin F, Duterque-coquillaud M
(2010) Exp Cell Res 316 :203-15
37. BMP-2, HYPOXIA, COLLAGEN SPONGES AND PARTICULAR INHIBITORS: AN INNOVATIVE COMBINATION FOR THE RECOVERY OF HUMAN CHONDROCYTE PHENOTYPE. APPLICATIONS FOR THE CELL THERAPY OF ARTICULAR CARTILAGE
Ollitrault D, Legendre F, Hervieu M, Bauge C, Maneix L, Renard E, Goux D, Leclercq S, Chajra H, Mallein-gerin F, Boumediene K, Demoor M, Galera P
(2010) Osteoarthritis And Cartilage 18 :S82-S82
2009
36. Molecular responses of chondrocytes cultured in agarose to dynamic compression
Bougault C, Paumier A, Aszodi A, Aubert-foucher E, Mallein-gerin F
(2009) International Journal Of Experimental Pathology 90 :A101-A101
35. Investigating conversion of mechanical force into biochemical signaling in three-dimensional chondrocyte cultures.
Bougault C, Paumier A, Aubert-foucher E, Mallein-gerin F
(2009) Nat Protoc 4 :928-38
34. Comparative phenotypic analysis of articular chondrocytes cultured within type I or type II collagen scaffolds.
Freyria Am, Ronziere Mc, Cortial D, Galois L, Hartmann D, Herbage D, Mallein-gerin F
(2009) Tissue Eng Part A 15 :1233-45
33. [Human chondrocyte responsiveness to bone morphogenetic protein-2 after their in vitro dedifferentiation: potential use of bone morphogenetic protein-2 for cartilage cell therapy].
Salentey V, Claus S, Bougault C, Paumier A, Aubert-foucher E, Perrier-groult E, Ronziere Mc, Freyria Am, Galera P, Beauchef G, Duterque-coquillaud M, Piperno M, Damour O, Herbage B, Mallein-gerin F
(2009) Pathol Biol (paris) 57 :282-9
32. Stable subclones of the chondrogenic murine cell line MC615 mimic distinct stages of chondrocyte differentiation.
Surmann-schmitt C, Widmann N, Mallein-gerin F, Von Der Mark K, Stock M
(2009) J Cell Biochem 108 :589-99
2008
31. Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression.
Bougault C, Paumier A, Aubert-foucher E, Mallein-gerin F
(2008) Bmc Biotechnol 8 :71-71
30. Collagen-based biomaterials and cartilage engineering. Application to osteochondral defects.
Chajra H, Rousseau Cf, Cortial D, Ronziere Mc, Herbage D, Mallein-gerin F, Freyria Am
(2008) Biomed Mater Eng 18 :S33-45
29. [Differentiation of adult human mesenchymal stem cells: chondrogenic effect of BMP-2].
Freyria Am, Courtes S, Mallein-gerin F
(2008) Pathol Biol (paris) 56 :326-33
28. Bone morphogenetic protein-2 stimulates chondrogenic expression in human nasal chondrocytes expanded in vitro.
Hautier A, Salentey V, Aubert-foucher E, Bougault C, Beauchef G, Ronziere Mc, De Sobarnitsky S, Paumier A, Galera P, Piperno M, Damour O, Mallein-gerin F
(2008) Growth Factors 26 :201-11
27. Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter.
Poree B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, Melin M, Gueret S, Hartmann Dj, Mallein-gerin F, Pujol Jp, Boumediene K, Galera P
(2008) J Biol Chem 283 :4850-65
2007
26. Influence of different collagen-based scaffolds (sponge or type I and II gels) on the phenotypic and collagenases expression of bovine chondrocytes
Freyria Am , Ronziere Mc , Cortial D , Herbage D , Mallein-gerin F
(2007) Tissue Engineering 13 :1715-1715
25. Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish.
Gouttenoire J, Valcourt U, Bougault C, Aubert-foucher E, Arnaud E, Giraud L, Mallein-gerin F
(2007) J Biol Chem 282 :30960-73
2006
24. Activation by IL-1 of bovine articular chondrocytes in culture within a 3D collagen-based scaffold. An in vitro model to address the effect of compounds with therapeutic potential in osteoarthritis.
Cortial D, Gouttenoire J, Rousseau Cf, Ronziere Mc, Piccardi N, Msika P, Herbage D, Mallein-gerin F, Freyria Am
(2006) Osteoarthritis Cartilage 14 :631-40
23. [Biomaterials and cell therapy in cartilage disorders].
Herbage D, Chajra H, Galois L, Freyria Am, Mallein-gerin F
(2006) Bull Acad Natl Med 190 :1399-1408
22. Thyroid hormone-stimulated differentiation of primary rib chondrocytes in vitro requires thyroid hormone receptor beta.
Rabier B, Williams Aj, Mallein-gerin F, Williams Gr, Chassande O
(2006) J Endocrinol 191 :221-8
21. A common pathway in differentiation and inflammation: p38 mediates expression of the acute phase SIP24 iron binding lipocalin in chondrocytes.
Ulivi V, Tutolo G, Mallein-gerin F, Daga A, Cancedda R, Cancedda Fd
(2006) J Cell Physiol 206 :728-37
2005
20. Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation.
Gomez C, Burt-pichat B, Mallein-gerin F, Merle B, Delmas Pd, Skerry Tm, Vico L, Malaval L, Chenu C
(2005) Dev Dyn 234 :393-403
19. Integrin alpha1beta1 mediates collagen induction of MMP-13 expression in MC615 chondrocytes.
Ronziere Mc, Aubert-foucher E, Gouttenoire J, Bernaud J, Herbage D, Mallein-gerin F
(2005) Biochim Biophys Acta 1746 :55-64
2004
18. Modulation of collagen synthesis in normal and osteoarthritic cartilage.
Gouttenoire J, Valcourt U, Ronziere Mc, Aubert-foucher E, Mallein-gerin F, Herbage D
(2004) Biorheology 41 :535-42
17. Gene expression analysis in cartilage by in situ hybridization.
Mallein-gerin F, Gouttenoire J
(2004) Methods Mol Med 100 :105-8
16. RNA extraction from cartilage.
Mallein-gerin F, Gouttenoire J
(2004) Methods Mol Med 100 :101-4
2003
15. Keratinocyte motility induced by TGF-beta1 is accompanied by dramatic changes in cellular interactions with laminin 5.
Decline F, Okamoto O, Mallein-gerin F, Helbert B, Bernaud J, Rigal D, Rousselle P
(2003) Cell Motil Cytoskeleton 54 :64-80
2002
14. Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes.
Valcourt U, Gouttenoire J, Moustakas A, Herbage D, Mallein-gerin F
(2002) J Biol Chem 277 :33545-58
13. Differential effects of osteogenic protein-1 (BMP-7) on gene expression of BMP and GDF family members during differentiation of the mouse MC615 chondrocyte cells.
Yeh Lc, Mallein-gerin F, Lee Jc
(2002) J Cell Physiol 191 :298-309
2001
12. Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis.
Bluteau G, Conrozier T, Mathieu P, Vignon E, Herbage D, Mallein-gerin F
(2001) Biochim Biophys Acta 1526 :147-58
1999
11. Different effects of bone morphogenetic proteins 2, 4, 12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line.
Valcourt U, Ronziere Mc, Winkler P, Rosen V, Herbage D, Mallein-gerin F
(1999) Exp Cell Res 251 :264-74
1996
10. Analysis of the chondrocyte phenotype in culture
Malleingerin F, Vanderrest M
(1996) M S-medecine Sciences 12 :1087-1096
1994
9. Localization of the expression of type I, II and III collagen genes in human normal and hypochondrogenesis cartilage canals.
Le Guellec D, Mallein-gerin F, Treilleux I, Bonaventure J, Peysson P, Herbage D
(1994) Histochem J 26 :695-704
1993
8. Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype.
Mallein-gerin F, Olsen Br
(1993) Proc Natl Acad Sci U S A 90 :3289-93
7. IDENTIFICATION AND LOCALIZATION OF FRANKIA STRAINS IN ALNUS NODULES BY INSITU HYBRIDIZATION OF NIF-H MESSENGER-RNA WITH STRAIN-SPECIFIC OLIGONUCLEOTIDE PROBES
Prin Y, Malleingerin F, Simonet P
(1993) Journal Of Experimental Botany 44 :815-820
1991
6. [Detection of mRNA by in situ hybridization in tissues fixed in Bouin's fixative and embedded in paraffin].
Treilleux I, Mallein-gerin F, Le Guellec D, Bouvier R, Berger F, Herbage D
(1991) Ann Pathol 11 :47-53
1990
5. Tendon collagen fibrillogenesis is a multistep assembly process as revealed by quick-freezing and freeze-substitution.
Mallein-gerin F, Garrone R
(1990) Biol Cell 69 :9-16
4. Proteoglycan core protein and type II collagen gene expressions are not correlated with cell shape changes during low density chondrocyte cultures.
Mallein-gerin F, Ruggiero F, Garrone R
(1990) Differentiation 43 :204-11
3. SUBEPITHELIAL TYPE-II COLLAGEN DEPOSITION DURING EMBRYONIC CHICK LIMB DEVELOPMENT
Malleingerin F
(1990) Rouxs Archives Of Developmental Biology 198 :363-369
1988
2. Temporal and spatial analysis of cartilage proteoglycan core protein gene expression during limb development by in situ hybridization.
Mallein-gerin F, Kosher Ra, Upholt Wb, Tanzer Ml
(1988) Dev Biol 126 :337-45
1986
1. PRESERVATION OF POLYGONAL SECTIONS AND INTERNAL DOMAINS BY QUICK-FREEZING OF COLLAGEN FIBRILS
Malleingerin F, Garrone R
(1986) International Journal Of Biological Macromolecules 8 :121-123
