Author Archives: Jerome Sohier

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flash présentation de l’équipe Biologie et Ingénierie du Cartilage

Une vidéo de présentation de l’équipe est présente sur youtube , dans le cadre du réseau OSCAR (réseau de recherche translationnelle): https://www.youtube.com/watch?v=ZomhMT5Yia8


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Offre de master M2 en biomécanique

Un master 2 est recherché pour travailler sur le projet : “Micro-mechanics of the vocal-fold tissue: experimental in situ mechanical tests using synchrotron imaging” à Grenoble.

Ce projet est en collaboration avec le LBTI dans le cadre de l’ANR MICROVOICE.

Master_internship_microvoice


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PhD Student pour une bourse Marie-Curie

Adjuvatis cherche un PhD Student pour une bourse Marie-Curie dans le cadre de l’ITN DRIVE

Adjuvatis, as one of the 15 beneficiaries of the Marie Sklodowska-Curie Actions Innovative Training Network DRIVE (Driving next generation autophagy researchers towards translation), is hiring a PhD Student for 3 years starting from May 2018. We are looking for a motivated and enthusiastic Early-Stage-Researcher to join our team and to work on the Design and Evaluation of Therapeutic Biodegradable Particles Inducing Autophagy as Tumor Suppressor Tool.

For more information about Adjuvatis (new web site coming soon) and the project, please contact Charlotte.Primard@adjuvatis.com.

This project will be co-supervised by the team Vecteurs Colloidaux et Transport Tissulaire from the LBTI. Please have a look on the DRIVE project website for more information about the consortium and how to apply: https://drive-autophagy.eu/.

Consortium & Training: https://drive-autophagy.eu/

Research project (ESR14): 
https://drive-autophagy.eu/

Contact: charlotte.primard@adjuvatis.com

Co-supervision: http://lbti.ibcp.fr/?page_id=1722


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Post-doctoral position Procollagen C-proteinase enhancers as therapeutic targets in cardiac fibrosis

Post-doctoral position

Procollagen C-proteinase enhancers as therapeutic targets in cardiac fibrosis

Project:  Cardiac fibrosis is the common consequence of several cardiovascular disorders, often leading to heart failure and death. Collagens are the main constituents of fibrotic tissues but there is presently no efficient therapy to limit their accumulation. Based on recent literature and on our previous work, procollagen C-proteinase enhancers (PCPEs), which can speed up collagen proteolytic maturation in a very efficient and specific manner, represent promising targets in cardiac fibrosis. In order to confirm this hypothesis and evaluate the impact of PCPE pharmacological inhibition, we have developed the first antagonists of PCPE activity which display very good potency in vitro. They will now be used to better describe PCPE functions in heart cells and assayed in vivo to evaluate their potential as diagnostic and therapeutic tools in an animal model of cardiac fibrosis. The project will be conducted in close collaboration with 3 other partners (Dijon University Hospital, NVH Medicinal and CGFL preclinical imaging platform).

Fellowship: funded by the CardiActiV ANR for 2 years, it will start beginning of 2018. Salary will depend on previous experience.

Host Institution: the LBTI (Tissue Biology and Therapeutic Engineering Laboratory – lbti.ibcp.fr) is a young and dynamic research laboratory located in the heart of Lyon Biodistrict (>5000 people working in life sciences and biomedical research). It offers top-level equipment in biology and a very stimulating scientific environment. Located in the South-East of France, Lyon is the second biggest scientific and economic center in the country and is internationally recognized for its quality of life.

Candidate: We are looking for a highly motivated candidate with good communication skills and capacity to work independently in a collaborative environment. The candidate will hold a PhD degree in life sciences, with a strong background in cell biology and in at least one of the following fields: heart physiopathology, extracellular matrix, proteolysis, proteomics. Experience in cell culture, cell and tissue imaging, quantitative PCR and biochemistry will also be needed.

Applicants should submit their complete application file (CV, cover letter, publication list and contacts for at least two references) by email before January 15, 2018.

Contact information:

Sandrine Vadon – Le Goff (Project coordinator)

LBTI, 7 Passage du Vercors, 69367 Lyon cedex 07, France

Email: sandrine.legoff@ibcp.fr

 

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